Polypeptide capable of efficiently inducing neogenesis of vascular tissues and use thereof

Abstract

The invention relates to a polypeptide capable of efficiently inducing neogenesis of vascular tissues. The polypeptide is characterized in that a polypeptide sequence is as follows: SCNSSSYSWYCWFGGSSPSWKYMVm-NH2. The polypeptide has high selectivity and strong affinity to a specific artificial composite material, can be non-covalently combined with the specific artificial composite material quickly, efficiently and stably, achieves modification of the artificial composite material in one step, and make the material have a biological function which significantly promotes the neogenesis of bloodvessels.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to a polypeptide capable of efficiently inducing neovascularization and its application. Background technique [0002] Artificial blood vessel transplantation is the main means of clinical treatment of vascular diseases. Due to their excellent biocompatibility, suitable mechanical properties and controllable degradation rate, artificial composite materials have received more and more attention in the field of vascular stent material research. However, the ability of simple artificial composite materials to spontaneously induce angiogenesis is weak. therefore. Functional modification of artificial composites to endow them with excellent pro-angiogenic ability is still necessary. [0003] At present, some polypeptides (such as WKYMVm, SP and CAG, etc.) have been proved to have the ability to induce angiogenesis. Therefore, in the prior art, these polypeptides are al...

AI Technical Summary

Problems solved by technology

However, the current method of modifying artificial composite materials with polypeptides mainly has the following technical problems: On the one hand, the affinity of polypeptides to artificial composite materials is poor, the formed binding is unstable, the binding force is small, and the binding rate is low. , the polypeptide will fall off, lose, and degrade quickly. On the other hand, the conditions required for modification are not conducive to maintaining the biological activity of the polypeptide. During the modification reaction, the ability of the polypeptide to promote angiogenesis will be greatly weakened or even lost.

However, this method still has the following technical problems: 1. The two polypeptides have high mutual selectivity. If the selection is not good, the two peptides will inhibit each other in function, which will lead to the inability to combine with artificial composite materials. Or the binding is unstable, or cannot play a growth-promoting role after binding

2. Poor selection and matching of peptide products and artificial composite materials will also hinder the growth-promoting function of peptides, so that peptide products cannot endow artificial composite materials with the ideal ability to induce angiogenesis

If the preparation reaction process is not well controlled, the angiogenesis-promoting ability of the obtained polypeptide product will be greatly weakened or even lost, and the affinity of the polypeptide product to the artificial composite material will be poor, and the formed combination will be unstable. Small, low binding rate, after entering the human body, it will quickly fall off, lose, and degrade

Images