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Application of tumor necrosis factor alpha-inducing protein 8-like molecule 1 in preparing medicine for treating fatty liver and related diseases

A technology of tumor necrosis factor and induced protein, which is applied in the application field of medicine to achieve the effect of high safety

Active Publication Date: 2018-06-29
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the role of TIPE1 in liver fat accumulation and degeneration

Method used

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  • Application of tumor necrosis factor alpha-inducing protein 8-like molecule 1 in preparing medicine for treating fatty liver and related diseases
  • Application of tumor necrosis factor alpha-inducing protein 8-like molecule 1 in preparing medicine for treating fatty liver and related diseases

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Embodiment Construction

[0032] The features and advantages of the present invention can be further understood through the following detailed description in conjunction with the accompanying drawings. The examples provided are only illustrative of the method of the present invention and do not limit the rest of the present disclosure in any way.

[0033] The reagents involved in the experiments in the present invention were purchased in domestic and foreign markets, or prepared by themselves according to the formula in the instructions; the experimental methods without special instructions all adopted conventional methods known in the art.

[0034] cell culture

[0035] The human liver cell line L02 was purchased from the Cell Bank of the Chinese Academy of Sciences (catalogue number GNHu6), and the human embryonic kidney HEK293T cells were purchased from the American type culture collection (ATCC). All the above cells were cultured in DMEM high-glucose medium (containing 10% FBS, 1% penicillin-strepto...

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Abstract

The invention discloses application of a tumor necrosis factor alpha-inducing protein 8-like molecule 1 in preparing a medicine for treating fatty liver and related diseases, and belongs to a new useof TIPE1. According to the application of the tumor necrosis factor alpha-inducing protein 8-like molecule 1 in preparing the medicine for treating the fatty liver and the related diseases, a human normal liver L02 cell line and a TIPE1 overexpressing L02 cell line are taken as objects of study, and a liver cell lipid accumulation model is induced by palmitate (PA) and oleic acid (OA) stimulationto study functions of a TIPE1 gene. The study finds that TIPE1 overexpression can significantly improve lipid accumulation in liver cells, indicating that TIPE1 can protect liver cells from fatty degeneration, and TIPE1 plays a protective role in liver lipid metabolism diseases. Since TIPE1 is an endogenous protein, the TIPE1 is high in safety as a drug.

Description

technical field [0001] The present invention belongs to the field of gene function and application, and specifically relates to the function and application of a tumor necrosis factor alpha induced protein 8 like 1 (TIPE1) gene in fatty liver and related diseases, specifically It is an application in the preparation of medicines for preventing, alleviating and / or treating fatty liver and related diseases. Background technique [0002] With the changes in the lifestyle and living environment of modern people, metabolic diseases such as obesity, lipid abnormalities, and diabetes have become major global diseases, seriously threatening the public's health and quality of life. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by the accumulation and degeneration of fat in liver cells without a history of excessive drinking. Its pathogenic factors include obesity, type Ⅱ diabetes, dyslipidemia and metabolic syndrome 1-3 . NAFLD is the most common c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K45/00A61K48/00A61P1/16A61P5/50A61P3/00A61P3/04A61P3/10A61P3/06A61P35/00G01N33/50G01N33/68G01N33/574
CPCA61K38/1709A61K45/00A61K48/005G01N33/5011G01N33/5067G01N33/574G01N33/57438G01N33/6863G01N2333/4715G01N2800/085
Inventor 李红良
Owner WUHAN UNIV
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