A kind of bombesin, medicine containing the bombesin and application thereof
A technology of bombesin and drugs, applied in the field of biomedicine, can solve the problems of insufficient direct treatment of epilepsy and other problems
Inactive Publication Date: 2020-07-10
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology
However, in the prior art, the direct therapeutic effect of bombesin on epilepsy is not obvious enough, and further improvement is needed.
Method used
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Embodiment
[0046] 1. In vitro experiments to verify the effect of methylated bombesin on GABA secretion.
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Abstract
The invention relates to the field of biomedicines and in particular relates to bombesin, a medicine containing the bombesin and application thereof. Arginine at a 3rd site of the bombesin is methylated bombesin. Compared with the bombesin, the methylated bombesin provided by the invention has a stronger effect of promoting neurons to release gamma-aminobutyric acid and the treatment effect of thebombesin on epilepsy can be remarkably enhanced.
Description
technical field [0001] The invention relates to the field of biomedicine, in particular to a bombesin, a medicine containing the bombesin and applications thereof. Background technique [0002] The incidence of epilepsy has increased year by year in the past ten years. According to the statistics of the World Health Organization at the end of 2012, there are about 50 million patients worldwide, and it has become the second most common nervous system disease after cerebrovascular disease. The latest epidemiological studies show that the average incidence of epilepsy worldwide is as high as 0.7%, and nearly 30% of them cannot be controlled by traditional drugs or other treatments, and then develop into "refractory epilepsy". The average life expectancy of nearly half of epilepsy patients is only 55 years old. While their quality of life has declined significantly, they have also added a lot of psychological and economic burdens to the family and society. The above situation is...
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IPC IPC(8): C07K7/08A61K38/10A61P25/08
CPCA61K38/00C07K7/08
Inventor 张昊鹏董海龙苏斌虓李慧明李文
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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