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CONSTRUCTION OF ONCOLYTIC HERPES SIMPLEX VIRUSES (oHSV) OBLIGATE VECTOR AND CONSTRUCTS FOR CANCER THERAPY

A herpes simplex virus, HSV-1 technology, applied in the direction of medical raw materials derived from viruses/phages, viruses/phages, introduction of foreign genetic material using vectors, etc. question

Active Publication Date: 2018-07-31
IMMVIRA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although systemic administration of single-chain antibodies against PD-1 or CTLA4 can effectively enhance the efficacy of oHSV, this is often accompanied by side effects and cannot be administered repeatedly over a long period of time

Method used

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  • CONSTRUCTION OF ONCOLYTIC HERPES SIMPLEX VIRUSES (oHSV) OBLIGATE VECTOR AND CONSTRUCTS FOR CANCER THERAPY
  • CONSTRUCTION OF ONCOLYTIC HERPES SIMPLEX VIRUSES (oHSV) OBLIGATE VECTOR AND CONSTRUCTS FOR CANCER THERAPY
  • CONSTRUCTION OF ONCOLYTIC HERPES SIMPLEX VIRUSES (oHSV) OBLIGATE VECTOR AND CONSTRUCTS FOR CANCER THERAPY

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Embodiment Construction

[0026] definition

[0027] It is to be noted that the term "a" or "an" entity refers to one or more of that entity; for example, "recombinant oncolytic HSV-1" is understood to mean one or more recombinant oncolytic HSV-1 viruses . Accordingly, the terms "a", "one or more" and "at least one" may be used interchangeably herein.

[0028] "Homology" or "identity" or "similarity" refers to the sequence similarity between two peptides or between two nucleic acid molecules. Homology can be determined by comparing the alignable positions in each sequence. When a position in the compared sequences is occupied by the same base or amino acid, then the molecules are homologous at that position. The degree of homology between sequences is related to the number of matching or homologous positions shared by the sequences. An "unrelated" or "non-homologous" sequence shares less than 40% identity, preferably less than 25% identity with one of the sequences herein.

[0029] A polynucleot...

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Abstract

An obligate oHSV vector comprising modified viral DNA genome is provided. A recombinant oHSV-1 construct comprising the obligate oHSV vector and a heterologous nucleic acid sequence encoding an immunostimulatory and / or immunotherapeutic agent is also provided. Compositions comprising the recombinant oHSV-1 construct can be used for treating cancers.

Description

technical field [0001] The present invention generally relates to the treatment of cancer using oncolytic herpes simplex virus (oHSV). Specifically, the present invention relates to the preparation of obligate (obligate) HSV vectors, which can carry and express multiple genes encoding immune co-stimulatory molecules and / or immunotherapeutic agents. The present invention also relates to an innovatively designed genome, which can be used as a carrier for carrying and expressing various therapeutic genes for treating cancer. Background technique [0002] Oncolytic herpes simplex virus (oHSV) is being studied extensively for the treatment of solid tumors. Oncolytic HSVs overall have many advantages over traditional cancer therapies (Markert et al., 2000; Russell et al., 2012; Shen and Nemunaitis, 2006). Specifically, oHSVs often contain mutations that render them susceptible to suppression of innate immunity. Thus, they are able to replicate in cancer cells, but not in normal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/869C12N15/33A61K48/00
CPCC12N15/86C07K14/5434C07K16/2818A61K35/763A61P35/00C12N2710/16643C12N2710/16621C12N2710/16632C07K2317/622A61K35/76A61K48/00
Inventor 周国瑛陈晓庆刘贤杰
Owner IMMVIRA CO LTD
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