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Method and system for microbiome-derived diagnostics and therapeutics for oral health

A technology of microbiota and microorganisms, applied in biochemical equipment and methods, measurement/testing of microorganisms, biostatistics, etc., can solve problems such as infeasibility

Active Publication Date: 2018-07-31
PSOMAGEN INC
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Problems solved by technology

However, current methods and systems for analyzing the human microbiome and delivering therapeutic measures based on the insights gained still leave many unanswered questions
In particular, approaches to characterize certain health conditions based on microbiome compositional or functional diversity profiles, as well as subject-specific adaptation of treatments (e.g., probiotic treatments), are not yet available due to limitations of current technologies. Row

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  • Method and system for microbiome-derived diagnostics and therapeutics for oral health
  • Method and system for microbiome-derived diagnostics and therapeutics for oral health
  • Method and system for microbiome-derived diagnostics and therapeutics for oral health

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Embodiment Construction

[0043] The inventors have discovered that characterization of an individual's microbiome can be used to detect microbiota indicative of dental caries or gingivitis. For example, an individual with symptoms indicative of caries or gingivitis, or suspected of having caries or gingivitis, can be tested to confirm or provide further evidence to support or refute the subject's diagnosis. As another example, individuals can be assayed to determine whether they have a microbiome that may increase the risk of dental caries or gingivitis. As another example, individuals with or suspected of having dental caries or gingivitis, or individuals with a history of dental caries or gingivitis, can be assayed to determine whether the microbiome may be a causative factor, or may increase caries or gingivitis frequency or severity. In this context, will have symptoms of dental caries or gingivitis, or suffer from dental caries or gingivitis, or have microbiota (e.g., oral, intestinal or fecal ...

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Abstract

Methods, compositions, and systems are provided for detecting one or more a oral health issues by characterizing the microbiome of an individual, monitoring such effects, and / or determining, displaying, or promoting a therapy for the oral health issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and / or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and / or therapy model for dental decay issues and gingivitis issues.

Description

[0001] Cross References to Related Applications [0002] This patent application claims priority to U.S. Provisional Application No. 62 / 215,924, filed September 9, 2015, and U.S. Provisional Application No. 62 / 215,909, filed September 9, 2015, the disclosures of each of which are in their entirety Incorporated herein for all purposes. Background technique [0003] The microbiome is the ecological community of commensal, commensal and pathogenic microorganisms associated with an organism. The human microbiome contains more microbial cells than human cells, but characterization of the human microbiome is still in its infancy due to limitations in sample handling techniques, genetic analysis techniques, and resources available to process large amounts of data . Nonetheless, the microbiome is suspected to play at least a partial role in many health / disease-related states (eg, preparing for childbirth, diabetes, autoimmune disorders, gastrointestinal disorders, rheumatoid disorde...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/689G06F19/10G06F19/18G06F19/20G16B20/20G16B30/10G16B40/20
CPCC12Q1/68C12Q1/6883C12Q1/689G16H50/50G16H50/20G16B20/00G16B30/00G16B40/00A61P1/00G16B30/10G16B20/20G16B40/20Y02A90/10G16H50/30A61K35/74
Inventor 扎迦利·阿普特杰西卡·里奇曼丹尼尔·阿尔莫纳西德斯亚沃什·瑞兹万·贝赫巴哈尼
Owner PSOMAGEN INC
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