Preparation method of temperature-sensitive type chitosan-based anti-acne aquagel for cosmetics

A chitosan and temperature-sensitive technology is applied in the field of preparation of a temperature-sensitive chitosan-based acne-removing hydrogel for cosmetics, and can solve the problems of easy inactivation, high salicylic acid irritation, skin peeling and the like, The preparation process is simple, the acne removal effect is good, and the stability is maintained.

Inactive Publication Date: 2018-08-03
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, antibiotics can cause anaerobic bacteria to develop drug resistance, and long-term use is not conducive to effective acne treatment; the strong oxidative properties brough

Method used

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  • Preparation method of temperature-sensitive type chitosan-based anti-acne aquagel for cosmetics
  • Preparation method of temperature-sensitive type chitosan-based anti-acne aquagel for cosmetics

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A preparation method of temperature-sensitive chitosan-based acne-removing hydrogel for cosmetics, characterized in that it comprises the following steps:

[0040] 1) Weigh 50 g of chitosan and 750 g of 1% acetic acid aqueous solution according to the mass ratio of 1:15 and mix them. After mixing, let them stand for 1 hour. Disperse and dissolve them by ultrasonic oscillator at 50°C. Ultrasound until the chitosan is completely dissolved; add a 0.2% aqueous NaOH solution to neutralize the pH to 6.0 to obtain an aqueous solution of chitosan;

[0041] 2) Weigh 300 g of β-glycerophosphate sodium and 750 g of distilled water respectively according to a mass ratio of 0.4:1 to make an aqueous solution of β-glycerophosphate sodium;

[0042] 3) Under the condition of 3°C ice bath, the chitosan aqueous solution and the β-glycerophosphate aqueous solution are mixed according to the mass ratio of 1:1, and the mixing process is that the β-glycerophosphate aqueous solution is slowly ...

Embodiment 2

[0048] A preparation method of temperature-sensitive chitosan-based acne-removing hydrogel for cosmetics, characterized in that it comprises the following steps:

[0049] 1) Weigh 100 g of chitosan and 1800 g of 1% acetic acid aqueous solution according to the mass ratio of 1:18 and mix them. After mixing, let it stand for 1 hour, and disperse and dissolve it by an ultrasonic oscillator at a temperature of 50 ° C. Ultrasound until the chitosan is completely dissolved; add a 0.2% aqueous NaOH solution to neutralize the pH to 6.3 to obtain an aqueous solution of chitosan;

[0050] 2) Weigh 500 g of β-glycerophosphate sodium and 1000 g of distilled water respectively according to a mass ratio of 0.5:1 to make an aqueous solution of β-glycerophosphate sodium;

[0051] 3) Under the condition of ice bath at 4°C, the chitosan aqueous solution and the β-glycerophosphate aqueous solution are mixed according to the mass ratio of 3:1, and the mixing process is that the β-glycerophosphate...

Embodiment 3

[0057] A preparation method of temperature-sensitive chitosan-based acne-removing hydrogel for cosmetics, characterized in that it comprises the following steps:

[0058] 1) Weigh 150 g of chitosan and 2550 g of 1% acetic acid aqueous solution according to the mass ratio of 1:17 and mix them. After mixing, let them stand for 1.7 hours. At 62 ° C, they are dispersed and dissolved by an ultrasonic oscillator. Ultrasound until the chitosan is completely dissolved; add a 0.2% aqueous NaOH solution to neutralize the pH to 6.3 to obtain an aqueous solution of chitosan;

[0059] 2) Weigh 208 g of β-glycerophosphate sodium and 416 g of distilled water respectively according to a mass ratio of 0.5:1 to make an aqueous solution of β-glycerophosphate sodium;

[0060] 3) Under the condition of ice bath at 3°C, mix the aqueous solution of chitosan and the aqueous solution of β-glycerophosphate at a mass ratio of 3:1. The mixing process is that the aqueous solution of β-sodium glycerophosph...

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Abstract

The invention relates to a preparation method of temperature-sensitive type chitosan-based anti-acne aquagel for cosmetics. The method is characterized by comprising the following steps of (1) preparing a chitosan water solution; (2) preparing a beta-sodium glycero-phosphate water solution; (3) under the 3-5 DEG C water bath condition, mixing the chitosan water solution and the beta-sodium glycero-phosphate water solution according to the mass ratio of (1 to 5):1 to obtain the chitosan/beta-sodium glycero-phosphate water solution; (4) preparing an alpha-mangostin ethanol solution; (5) preparing a genipin-aucubin water solution; (6) mixing the chitosan/beta-sodium glycero-phosphate water solution and the alpha-mangostin ethanol solution according to a mass ratio of (20 to 100):1 to preparethe alpha-mangostin-chitosan/beta-sodium glycero-phosphate water solution; (7) performing crosslinking on the alpha-mangostin-chitosan/beta-sodium glycero-phosphate water solution and the genipin-aucubin water solution according to the mass ratio of (100 to 200):1 at 78 to 80 DEG C to obtain the anti-acne aquagel. The preparation method has the advantages that the preparation process is simple; safety and nontoxicity are realized; the obtained anti-acne aquagel has a good anti-acne effect and high safety; the use is convenient, and the like.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a preparation method of a temperature-sensitive chitosan-based acne-removing hydrogel for cosmetics. Background technique [0002] Modern people have various skin problems due to climate problems, environmental pollution, sub-health problems and many other factors, among which acne problems account for a large proportion. According to authoritative statistics from the Ministry of Health in 2017, consumers with acne problems in my country are With an increase of 4-6 million person-times per year, effective acne treatment has become an important topic in the study of problematic skin in recent years. [0003] Excessive sebum secretion, abnormal keratinization of hair follicles, and stimulation of anaerobic bacteria in hair follicles can lead to acne. The current methods of treating acne mainly contain oral drug method and topical application method. The oral drug method is mainl...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/49A61K8/04A61Q19/00A61P17/10
CPCA61K8/042A61K8/498A61K8/736A61K2800/548A61Q19/00A61P17/10
Inventor 李欣航蒋丽刚张金龙王玲席长洪王晗宁
Owner PROYA COSMETICS
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