Application of hyodeoxycholic acid to preparation of medicines for losing weight and treating or preventing obesity complications

A technology for hyodeoxycholic acid and complications, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as fat reduction, reduce fat weight and density, increase leptin sensitivity, Significant weight loss effect

Inactive Publication Date: 2018-08-10
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But whether hyodeoxycholic acid has weight loss effect has never been reported
[0005] Although lipid-lowering drugs can reduce the blood lipid content in the blood, this does

Method used

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  • Application of hyodeoxycholic acid to preparation of medicines for losing weight and treating or preventing obesity complications
  • Application of hyodeoxycholic acid to preparation of medicines for losing weight and treating or preventing obesity complications
  • Application of hyodeoxycholic acid to preparation of medicines for losing weight and treating or preventing obesity complications

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Experimental program
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Effect test

Embodiment 1

[0039] 1. Preparation of animal models: A total of 16 2-month-old mice were selected and fed with a feed containing 60% fat (ResearchDiet, D12492 high-fat feed) to induce obesity. Obese mouse models were obtained when the mice were 5 months old.

[0040] 2. Grouping: Select 16 obese mouse models and divide them into two groups, the hyodeoxycholic acid group and the high-fat control group. In addition, 8 5-month-old mice with normal feeding (the feed contains 10% fat, Chow diet) are set as normal control group. The mice in the hyodeoxycholic acid group were intraperitoneally injected with hyodeoxycholic acid at a ratio of 2 mg / kg body weight, once a day, and the hyodeoxycholic acid was dissolved in normal saline when used; The same amount of normal saline was injected daily for a total of 28 days.

[0041] 3. Record the body weight of the mice in each group every day, and measure the food intake of the mice in each group 28 days after administration.

[0042] 4. After 28 days...

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Abstract

The invention provides application of hyodeoxycholic acid to preparation of medicines for losing weight. After hyodeoxycholic acid is used for injecting high-fat feed-induced obese mice, the food intake of the mice is decreased by 30% compared with a control group, the body weights of the mice are decreased by 30% or above, and the fat weight and fat density of the mice are significantly reduced;therefore, hyodeoxycholic acid provided by the invention is proved to have a significant weight-loss effect and can be applied to the preparation of the weight-reducing medicines with a significant weight reducing effect. The invention also provides application of hyodeoxycholic acid in the preparation of medicines for treating or preventing obesity complications; the obesity complications are a series of diseases caused by metabolic disorders due to obesity.

Description

technical field [0001] The invention relates to the field of weight-loss drugs, in particular to the application of hyodeoxycholic acid in the preparation of weight-loss drugs and the application of hyodeoxycholic acid in the preparation, treatment or prevention of obesity complications. Background technique [0002] Obesity is a chronic metabolic disease caused by a variety of factors, characterized by an increase in the volume and number of fat cells in the body, resulting in an abnormally high proportion of body fat to body weight, and excessive deposition of fat in some areas. At present, obesity has become a serious global medical and social problem. The incidence of diseases such as cerebral embolism, heart failure, coronary heart disease and diabetes in obese patients is 1-4 times higher than that of normal weight people, and their life expectancy is shortened by 4 years compared with normal weight people. Obesity can lead to chronic diseases such as diabetes and hig...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P3/04A61P1/16A61P3/10
CPCA61K31/575A61P1/16A61P3/04A61P3/10
Inventor 黄诚姚寅范圣洁李鸿丽
Owner SHANGHAI UNIV OF T C M
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