Preparation method of effective hemostatic material applicable to open drowning wounds

Abstract

The invention relates to a preparation method of an effective hemostatic material applicable to open drowning wounds, and belongs to the technical field of a medical material. The method is characterized in that a soluble copper salt solution with the concentration being 1 to 10mM is prepared; a fiber hemostatic material is impregnated in the soluble copper salt solution; stirring is performed; the fiber hemostatic material is taken out and is flushed by distilled water for three times; the fiber hemostatic material containing Cu<2+> at the surface is obtained; disodium hydrogen phosphate, monopotassium phosphate, sodium chloride and potassium chloride are weighed; a PBS solution is prepared; thrombin is added into the PBS solution, so that the thrombin concentration is 0.01 to 1g / L; the fiber hemostatic material containing Cu<2+> at the surface is impregnated in the PBS solution containing the thrombin; stirring is performed; then, the fiber hemostatic material is taken out and flushed by distilled water for three times; the effective hemostatic material for open drowning wounds is obtained. The preparation process of the open drowning wound hemostatic material is mild and simpleand achieves an environment-friendly effect; high-temperature environment, organic reagents or specific equipment is not needed; the structure and active sites of the thrombin are favorably reserved;the preparation method is suitable for expanded large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a high-efficiency hemostatic material suitable for open drowning wounds. Background technique [0002] With the continuous increase in the development and utilization of marine resources in modern society, various types of traumatic injuries at sea are also increasing year by year. Due to the particularity of the offshore operating environment, the wounded are prone to fall into the water and form open drowning wounds, and coagulation dysfunction is more likely to be caused by the impact of seawater, immersion, low temperature, and high permeability. In addition, the wounded at sea are often far away from land, with limited medical resources and various conditions, so they cannot receive timely treatment. Even minor trauma will greatly increase the risk of bleeding and death due to delayed hemostasis. Therefore, it is very necessary ...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that open drowning wounds are prone to coagulation dysfunction, and to provide a method for preparing a high-efficiency hemostatic material suitable for open drowning wounds

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