Composition for treating and preventing viral infections
A composition and influenza virus technology, applied in antiviral agents, antiviral immunoglobulins, plant raw materials, etc., can solve problems such as reduced patient compliance
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Embodiment 1
[0161] (compound characterization by exact mass and relative abundance)
[0162] The inventors have surprisingly discovered that a combination of several compounds found in elderberry can prevent and treat influenza virus infection. The inventors have also discovered that certain relative concentrations of the compounds act to enhance the ability of the combined compounds to prevent and treat influenza virus infection. Furthermore, the inventors have discovered that administration of the compounds of the present invention with additional anti-influenza compounds also enhances the ability of the combined compounds to prevent and treat influenza virus infection. Compositions of the invention comprise compound-defined biomarker compounds found in elderberry having exact masses of 112.027 amu, 126.032 amu, 155.095 amu, 160.087 amu, 166.099 amu, and 507.342 amu. These compounds can be prepared synthetically or isolated from organisms such as, but not limited to, Western elderberry...
Embodiment 2
[0184] (for the formulations of Example 3 to Example 8)
[0185] Dosed elderberry extracts comprising biomarkers 1 to 9 with antiviral activity in vitro and in vivo were generally prepared according to the methods described in Fink et al. 2009 and Roschek Jr. et al. 2009.
[0186] Generally, elderberries (Sambucus nigra) are ground and washed with EtOH:H 2 O (4:1, v / v) extraction. The collected fractions were dried overnight at 50 °C to yield a crystalline powder. Repeat steps several times to ensure extract reproducibility.
Embodiment 3
[0188] (safety)
[0189] HSRx 351 was tested to determine in vitro cytotoxicity. HSRx 351 showed no signs of toxicity as determined using a standard mitochondrial reductase activity assay (MTT). MTT assay measures cellular metabolism in MDCK cells. No toxicity was shown at any concentration tested (0.02 mg / ml to 2.4 mg / ml).
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