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Compositions with specific oligosaccharides to prevent later in life obesity or related comorbidities, by increasing colonic scfa production and/or by increasing glp-1 secretion

A technology of GLP-1 and oligosaccharides, applied in the field of nutritional compositions

Pending Publication Date: 2018-09-04
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of these existing documents mention or show the effect of BMO on colonic SCFA production and / or GLP-1

Method used

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  • Compositions with specific oligosaccharides to prevent later in life obesity or related comorbidities, by increasing colonic scfa production and/or by increasing glp-1 secretion
  • Compositions with specific oligosaccharides to prevent later in life obesity or related comorbidities, by increasing colonic scfa production and/or by increasing glp-1 secretion
  • Compositions with specific oligosaccharides to prevent later in life obesity or related comorbidities, by increasing colonic scfa production and/or by increasing glp-1 secretion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] Table 1 below gives an example of the composition of an infant formula comprising an oligosaccharide mixture according to the invention. The oligosaccharide mixture may, for example, comprise 0.1 to 4.0% by weight of N-acetylated oligosaccharides, 92.0 to 99.5% by weight of galacto-oligosaccharides and 0.2 to 4.0% by weight of sialylated oligosaccharides.

[0193]

[0194]

[0195] Table 1 : Examples of compositions of nutritional compositions (eg infant formulas) according to the invention

Embodiment 2

[0197] research description

[0198] Five-week-old female BALB / cByJ CRL mice from Charles River were divided into groups and fed during 6 weeks based on the following schedule:

[0199] - Week 1: all groups: low fiber diet (see Table 2 for composition)

[0200] - Week 2 to Week 6:

[0201] Control group (group A): low fiber diet (same as week 1)

[0202] · Test groups (groups B to D): low fiber diet supplemented with 5% by weight of test fiber (replacing 5% of the total low fiber diet with 5% of test fiber) (same as week 1)

[0203]

[0204]

[0205] Table 2: Components of a low-fiber diet

[0206] The following fibers were tested:

[0207] Test BMO = milk oligosaccharides: oligosaccharide mixture comprising 99.3% GOS, 0.2% N-acetylated oligosaccharides and 0.5% sialylated oligosaccharides

[0208] PDX = polydextrose

[0209] pectin

[0210]Table 3 provides a summary of the different test groups and diets.

[0211]

[0212]

[0213] Table 3: Study tes...

Embodiment 3

[0225] research description

[0226] Cell Lines and Culture Conditions

[0227] Human NCI-H716 cells were obtained from the American Type Culture Collection. These cells are human endocrine cells capable of secreting GLP-1.

[0228] For the maintenance of proliferation, these cells were supplemented with 10% FBS (fetal bovine serum), 2mm l-glutamine, 100IU / mL penicillin and 100μg / mL streptomycin Grow in suspension in RPMI 1640. Initiation was initiated by growing cells on Matrigel (high glucose DMEM (Dulbecco's Modified Eagle's Medium), 10% FBS, 2 mm l-glutamine, 100 IU / mL penicillin and 100 μg / mL streptomycin) coated dishes. Cell attachment and endocrine differentiation.

[0229] Secretion studies

[0230] Two days before the experiment, 1×10 6 NCI-H716 cells were seeded in Matrigel-coated 12-well culture plates. On the day of the experiment, replace the supernatant with KRB buffer (Krebs-Ringer bicarbonate buffer) with or without test reagents:

[0231] KRB b...

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Abstract

The present invention relates to a nutritional composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide for use in reducing and / or avoiding excessive fat mass accumulation and / or in preventing anyrelated later in life health disordersin an infant or a young child such as later in life obesity and related comorbidities, by increasing colonic SCFA production and / or GLP-1 secretion / releasein said infant or young child.

Description

technical field [0001] The present invention relates to nutritional compositions such as infant formulas comprising a mixture of oligosaccharides specifically designed to avoid excessive accumulation of fat mass and Related later health disorders such as later obesity are prevented in said infant or young child. Background technique [0002] Scientific evidence suggests that infancy may be a critical period for future health conditions including the emergence and programming of later obesity or future related co-morbidities, including metabolic disorders. [0003] Overweight and obesity are defined as abnormal or excessive accumulation of fat that may impair health. Body mass index (BMI), as a simple body mass index for height, is commonly used to classify overweight and obesity in adults. It is defined as a person's weight (kg) divided by the square (kg / m2) of a person's height (m). The definition of WHO is: BMI greater than or equal to 25 is overweight; BMI greater than...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A23L33/00
CPCA61K31/702A23L33/21A23L33/40A61P3/04A23V2002/00A23V2200/3202A23V2200/3204A23V2200/332A23V2250/284A61K2035/115
Inventor A·比尼亚C·南布里尼N·斯普伦格O·阿万蒂尼格罗
Owner SOC DES PROD NESTLE SA
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