Compounds of Formula (I),are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are
hydrogen, optionally substituted lower
alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is
hydrogen or optionally substituted lower
alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is
hydrogen,
halogen, CF3,
diene fused to Y when Y═C, or substituted
diene fused to Y when Y═C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen,
halogen, or optionally substituted lower
alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta
amyloid production and for treatment of Alzheimer's
Disease and Down'
s syndrome are also described.