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Screening of active site with anti-cervicitis effect in callicarpa nudiflora

A technique of extracting Auranthus nudiflora, which is applied to medical preparations containing active ingredients, diseases, plant raw materials, etc., and can solve the problem that the extraction rate of Aurantia nudiflora is not given clearly, and the therapeutic effect is different or different. Research and other issues to achieve the effect of improving resource utilization, reducing losses, and high purity of total tannins

Inactive Publication Date: 2018-09-14
HUANGHE S & T COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0026] However, the invention did not study the extraction rates of different parts of different nudibranchs, and did not further study the different types of cervicitis according to the theory of traditional Chinese m

Method used

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  • Screening of active site with anti-cervicitis effect in callicarpa nudiflora
  • Screening of active site with anti-cervicitis effect in callicarpa nudiflora
  • Screening of active site with anti-cervicitis effect in callicarpa nudiflora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take 1kg of fresh Auranthus nudiflorum leaves harvested in October, add 2kg of water, crush it into a homogenate, press, filter, concentrate, and dry to obtain 107.8g of extract. The flavonoid content is 58.9mg / g, the luteolin content is 0.68mg / g, and the total tannin content is 17.35 mg / g.

Embodiment 2

[0051] Take 1kg of the fresh root bark of Auranthus nudiflorum harvested in October, add 2kg of water and crush it into a homogenate, press, filter, concentrate, and dry to obtain 89.7g of extract. The total flavonoid content is 50.7 mg / g, the luteolin content is 0.51 mg / g, and the total tannin content is 15.34 mg / g.

Embodiment 3

[0053] Take 1 kg of fresh Auranthus nudiflora leaves harvested in October, crush them to obtain Auranthus nudiflora slurry, add 10 times of 95% ethanol to extract and recover the solvent to obtain extract 1; add 10 times the amount of chloroform to extract and recover the solvent to obtain extract 1 Material 2; the remaining residue was extracted with 10 times of normal hexane heat reflux, and then the n-hexane was recovered to obtain extract 3; the combined extracts 1, 2, and 3 were dried to obtain 98.8g of the total extract of Auranthus nudica. The acquisition rate was 9.88%. The measured total flavonoid content was 53.4 mg / g, the luteolin content was 0.56 mg / g, and the total tannin content was 16.57 mg / g.

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Abstract

The invention relates to the field of traditional Chinese medicine extraction, in particular to an extraction method of callicarpa nudiflora and application of extracts of different sites in treatingcervicitis. Since no research on the extraction content of effective components of different sites of callicarpa nudiflora in the prior art, and on the uniformity of the in vitro experiment and clinical curative effect of the extract, and particularly on the consistency of the therapeutic effect of the extract in western medicine and clinical corresponding curative effect of the traditional Chinese medicine diagnosis, the screening is carried out; the screening aims to: 1, providing a preparation method of a callicarpa nudiflora extract, which is, more comprehensively, extracting components incallicarpa nudiflora; a callicarpa nudiflora extract is characterized in that the raw material is callicarpa nudiflora in a fresh state, and the preparation method comprises the following steps of: extracting and concentrating the fresh raw material to obtain the callicarpa nudiflora extract.

Description

technical field [0001] The invention relates to the field of extracting traditional Chinese medicines, in particular to the extracting method of Aurora nudiflora and the application of extracts from different parts in treating cervicitis. Background technique [0002] Cervicitis (cervicitis) is one of the common gynecological diseases. It is more common in women of childbearing age. It is caused by damage to the cervix and invasion of pathogens, including inflammation of the cervix and vagina and mucous membranes of the cervix. Clinically, cervicitis is divided into acute and chronic, with chronic inflammation as the majority. [0003] The survey of Chinese women by the World Health Organization shows that the number of women of childbearing age in my country is about 150 to 200 million, of which about 41% of women suffer from gynecological inflammatory diseases to varying degrees, and the incidence rate of married women is as high as 70%. According to statistics, cerviciti...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P15/00A61K135/00A61K127/00A61K125/00
CPCA61K36/85A61K2236/31A61K2236/333A61K2236/35A61K2236/51A61P15/00
Inventor 杨娟董亚娜龙文义候辉丽
Owner HUANGHE S & T COLLEGE