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Composition for treating juvenile herpangina and application thereof

A technique for herpetic angina and composition, which is applied in the field of extract composition of Viola nudiflora, can solve the problems of complex effective ingredients, unclear effective ingredients, poor controllability of quality standards, etc., and achieves remarkable curative effect, composition and The effect of clear content and stable quality

Active Publication Date: 2018-09-14
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prior art has the disadvantages of complex active ingredients, unclear active ingredients, and poor controllability of quality standards, making it difficult to meet the requirements of "safe, effective, controllable, and stable" drugs.

Method used

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  • Composition for treating juvenile herpangina and application thereof
  • Composition for treating juvenile herpangina and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Extraction of total flavonoids, total phenolic acids, phenylethanol glycosides and polysaccharides of Auranthus nudica

[0054] (1) Preparation of the water extract of Auranthus nudiflora:

[0055] Add water to 100°C and extract 3 times, add 8 times of water each time, extract for 2.5 hours for the first time, and extract for 0.5 hours for the second and third times, combine the filtrates, filter, and concentrate under reduced pressure at 60°C to a relative density of 1.30-1.35 In the form of extract, dried at 60°C to dry extract, set aside;

[0056] (2) Preparation of total flavonoids from Auranthus nudica:

[0057] ① Dissolve the water extract of Aurora nudiflora in ethanol, and prepare a 0.5mg / mL ethanol solution of Aurora nudiflora;

[0058] ②The ethanol solution of Auranthus nudica was passed through AB-8 resin (the ratio of diameter to height was 1:15), 95% ethanol was used as eluent, the injection rate was 1.5mL / min, the elution rate was 20 drops / min,...

Embodiment 2

[0072] Example 2 Extraction of total flavonoids, total phenolic acids, phenylethanol glycosides and polysaccharides of Auranthus radiata

[0073] (1) Preparation of the water extract of Auranthus nudiflora:

[0074] Add water 105°C to extract 2 times, each time add 10 times of water, extract for 2 hours for the first time, extract for 1 hour for the second time, combine the filtrate, filter, concentrate under reduced pressure at 80°C to an extract with a relative density of 1.30-1.35 , dried at 70°C to form a dry extract, and set aside;

[0075] (2) Preparation of total flavonoids from Auranthus nudica:

[0076] ①The water extract of Aurora nudiflorum, dissolved in ethanol, is prepared as 0.8mg / mL ethanol solution of Aurora nudiflora;

[0077] ②The ethanol solution of Aurantia nudica is passed through AB-8 resin (the ratio of diameter to height is 1:10), 90% ethanol is used as the eluent, the injection rate is 2mL / min, the elution rate is 25 drops / min, and the eluted After ...

Embodiment 3

[0091] Example 3 Extraction of total flavonoids, total phenolic acids, phenylethanol glycosides and polysaccharides of Auranthus nudica

[0092] (1) Preparation of the water extract of Auranthus nudiflora:

[0093]Add water to 110°C for extraction once, add 12 times of water each time, extract for 1 hour for the first time, extract for 3 hours for the second time, combine the filtrates, filter, concentrate under reduced pressure at 90°C to an extract with a relative density of 1.30-1.35 , dried at 75°C to form a dry extract, and set aside;

[0094] (2) Preparation of total flavonoids from Auranthus nudica:

[0095] ①The water extract of Auranthus nudiflorum, dissolved in ethanol, is prepared as 1mg / mL ethanol solution of Aurora nudiflora;

[0096] ②The ethanol solution of Auranthus nudica is passed through AB-8 resin (the ratio of diameter to height is 1:8), 85% ethanol is used as the eluent, the injection rate is 3mL / min, the elution rate is 30 drops / min, and the eluted Af...

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Abstract

The invention belongs to the field of Chinese medicine and particularly provides a composition for treating juvenile herpangina. The composition is prepared from, by weight, 40-50 parts of callicarpanudiflora general flavone, 10-20 parts of callicarpa nudiflora general phenolic acid, 20-30 parts of callicarpa nudiflora general phenylethanoid glycosides and 2-6 parts of callicarpa nudiflora polysaccharide. The invention also discloses application of the composition. The four components are all extracted from callicarpa nudiflora, are definite and cooperate with one another to take an effect, and the composition has a great effect of treating and / or preventing juvenile herpangina.

Description

technical field [0001] The present invention relates to an extract composition of Auranthus nudiflora and its application, in particular to an extract composition of Auranthus nudiflora with the effect of treating herpetic angina in children and an application thereof. Background technique [0002] Herpetic angina is an acute contagious pharyngitis characterized by acute fever and herpetic ulcers in the isthmus caused by enteroviruses. The main transmission route is feces-oral or respiratory. It is highly contagious and spreads quickly throughout the All over the world, it is sporadic or prevalent, and summer and autumn are the high incidence seasons, mainly affecting children aged 1 to 7 years old. [0003] The main clinical manifestations are fever, sore throat, pharyngeal isthmus mucosa small herpes and superficial ulcers. Patients with herpetic pharyngitis and recessive infection are the main source of infection of this disease. It can be transmitted directly through t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P31/14A61P11/04A61P29/00
CPCA61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P11/04A61P29/00A61P31/14A61K2300/00
Inventor 陈梁李小锋张金良周朝忠杨伟庆
Owner JIANGXI POZIN PHARMA
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