Application of alkaloid compound in preparation of anti-obesity medicine

A technology of alkaloids and compounds, applied in biochemical equipment and methods, microorganisms, drug combinations, etc., can solve the problem of no research report on biological activity, and achieve the effect of inhibiting fat accumulation and good anti-obesity function.
CN108546247BActive Publication Date: 2020-11-24ZHOUKOU NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHOUKOU NORMAL UNIV
Publication Date
2020-11-24

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Abstract

The invention relates to a use of an alkaloid compound in preparing an anti-obesity drug. The alkaloid compound or a pharmaceutically acceptable salt thereof is of a structure shown as a formula I; and the invention relates to a use of structural analogs alone or in the form of a composition in preparing the anti-obesity drug. Fermentation culture is performed on aspergillus terreus ML-44 from seato acquire a leavening containing a compound shown in the formula I, and separation and purification are performed on the leavening to obtain the compound shown in the formula I, wherein as for the aspergillus terreus ML-44, a preservation number is CGMCC No. 15664, a preservation date is 17 April, 2018, and a preservation place is China General Microbiological Culture Collection Center (CGMCC).By adopting the use provided by the invention, the compound and the structural analogs thereof have the anti-obesity activity, a lead compound is provided to develop a novel anti-obesity drug. (The formula I is described in the description).
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Description

technical field

[0001] The invention relates to the use of an alkaloid compound in the preparation of anti-obesity medicine. Background technique

[0002] With the development of society and economy, the incidence of obesity in my country is increasing year by year, and the number of patients has increased from 2.4 million in 1975 to more than 90 million in 2014, accounting for 14.3% of the obese population in the world (NCD Risk Factor Collaboration, Trends in adult body- mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19•2 million participants. The Lancet, 2016, 387, 1377–1396). Obesity is closely related to the occurrence of a series of chronic diseases such as type II diabetes, cardiovascular and cerebrovascular diseases, and cancer (Smith and Minson, Obesity and adipokines: effects on sympathetic overactivity. J Physiol, 2012, 590, 1787–1801; Singer and Lumeng, The initiation of metabolic inflammation in...

Claims

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