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Application of protein C to preparation of medicine for preventing and treating pulmonary arterial hypertension disease

A pulmonary arterial hypertension, pulmonary arterial technology, applied in the application field of protein C in the preparation of drugs for the prevention and treatment of pulmonary arterial hypertension, to achieve the effect of reducing the ratio, inhibiting the proliferation of pulmonary artery smooth muscle cells, and inhibiting the proliferation of pulmonary artery smooth muscle cells in rats with pulmonary arterial hypertension

Pending Publication Date: 2018-09-21
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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AI Technical Summary

Problems solved by technology

[0005] At present, there is no report of coagulation protein PC in the preparation of drugs for the prevention and treatment of pulmonary arterial hypertension

Method used

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  • Application of protein C to preparation of medicine for preventing and treating pulmonary arterial hypertension disease
  • Application of protein C to preparation of medicine for preventing and treating pulmonary arterial hypertension disease
  • Application of protein C to preparation of medicine for preventing and treating pulmonary arterial hypertension disease

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Experimental program
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Embodiment 1

[0022] Application of coagulation protein PC in the preparation of medicines for preventing and treating pulmonary hypertension:

[0023] 1) Determination of 14-3-3σ protein as a marker of pulmonary hypertension: Through bioinformatics analysis, it was found that 14-3-3β was associated with an increase in pulmonary hypertension patients, and then animal experiments were carried out to treat pulmonary hypertension model rats Lung tissue was tested by western-blotting, and 7 subtypes of 14-3-3 protein (β, ε, η, γ, σ, τ, ζ) were detected at the same time. It was found that only 14-3-3σ was expressed in pulmonary arterial hypertension The expression in the lung tissue of model rats was significantly reduced, and its expression was increased in the PC treatment group. Therefore, 14-3-3σ protein can be used as a marker of pulmonary hypertension and as an auxiliary detection index.

[0024] 2) Male SD rats (4 weeks old) were randomly divided into 3 groups: control group, pulmonary h...

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Abstract

The invention belongs to the technical field of new application of medicines and particularly discloses application of protein C to preparation of medicine for preventing and treating a pulmonary arterial hypertension disease. The applicant discovers that blood coagulating protein PC can promote monocrotaline to induce expression of 14-3-3 sigma in lung tissues of pulmonary arterial hypertension model rats so as to inhibit proliferation of pulmonary arterial smooth muscle cells of the pulmonary arterial hypertension rats. The therapeutic research result shows that the blood coagulating proteinPC has the curative effects of obviously inhibiting proliferation of the pulmonary arterial smooth muscle cells, reducing right ventricular systolic pressure and reducing the ratio of right ventricular weight to left ventricular plus interventricular weight. The invention discloses the effect of the protein C to treatment on the pulmonary arterial hypertension disease for the first time and provides medicine basis for treating the pulmonary arterial hypertension disease.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of protein C in the preparation of medicines for preventing and treating pulmonary hypertension. Background technique [0002] Pulmonary hypertension (PH) is a clinical hemodynamic syndrome characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance. The important pathophysiological basis of its development is pulmonary vasoconstriction, proliferation of endothelial cells and smooth muscle cells, and in situ thrombus formation. This implies that there are perturbations in the normal relationships between vasodilators and vasoconstrictors, growth inhibitors and mitogenic factors, and antithrombotic and prothrombotic determinants. These homeostatic imbalances may be a consequence of pulmonary vascular endothelial cell dysfunction or injury. PH can lead to right heart failure and even death directly. The pathog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K45/06A61P11/00A61P9/12
CPCA61K38/1709A61K45/06A61P9/12A61P11/00
Inventor 曾和松刘玉建王洪杰
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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