Pre-filled preparation of clinical first-aid traditional Chinese medicine injection
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A pre-filling and injection technology, applied in syringes, infusion sets, pharmaceutical formulations, etc., to achieve efficient treatment, ensure safety, and be less prone to errors.
Inactive Publication Date: 2018-09-28
WUXI JIMIN KEXIN SHANHE PHARMA +1
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[0002] At present, the packaging of water injections for clinical use in China is almost all in ampoule packaging. When using, the neck of the glass ampoule needs to be cut, and then inhaled into a sterile syringe, injected into the patient or added to the infusion bottle for intravenous drip, intramuscular injection, etc. , there will inevitably be the risk of secondary pollution such as glass debris entering the liquid medicine and stabbing the operator's fingers
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Embodiment 1
[0029] Embodiment 1: the present invention provides a kind of pre-filled preparation of clinical first aid Chinese medicine injection, it is characterized in that, the steps are as follows:
[0030] (1) Turmeric, gardenia, musk, medicinal material samples, crushed and sieved, set aside,
[0031] (2) After pulverization, turmeric, gardenia, and musk are distilled for supercritical extraction respectively to obtain volatile oil
[0032] (3) Borneol is added with a solubilizer, pulverized, and the solubilizer is polyethylene glycol 400, etc.
[0033] (4) the mixture of borneol and solubilizer is added in the step (2) volatile oil mixed solution, sodium chloride solution is added, and the pH is adjusted for subsequent use.
[0034] (5) After sterilizing the liquid medicine in step (4), pour it into a glass (neutral) pre-filled syringe, put the push rod and piston into it and seal it, sterilize it with ethylene oxide, and then label it and seal it in plastic.
Embodiment 2
[0035] Embodiment 2, the present invention provides a kind of clinical emergency Chinese medicine injection pre-filled preparation, it is characterized in that, the steps are as follows:
[0036] (1) Turmeric, gardenia, musk, medicinal material samples, crushed and sieved, set aside,
[0037] (2) after crushing, turmeric, gardenia, and musk are distilled to extract the distillate,
[0038] (3) Borneol is added with a solubilizer, crushed, and the solubilizer is Tween-80
[0039] (4) Add the mixture of borneol and solubilizer to step (2) distillate, add sodium chloride, adjust PH for subsequent use,
[0040] (5) After sterilizing the medicinal solution in step (4), pour it into a plastic (PP) pre-filled syringe, put the push rod and piston into it and seal it, and then sterilize it with ethylene oxide, then label and seal it.
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Abstract
The invention discloses a pre-filled preparation of clinical first-aid traditional Chinese medicine injection. The pre-filled preparation of the clinical first-aid traditional Chinese medicine injection contains the xingnaojing injection, a method comprises the steps that 1, curcumae radix, fructus gardeniae and moschus are regarded as medicinal material samples and subjected to crushing and screening for later use; 2, after crushing, the curcumae radix, the fructus gardeniae and the moschus are subjected to distillation to extract a distillate or the three medicinal materials are subjected toa supercritical extraction technology separately to collect essential oil; 3, borneol is added to a solubilizer, and crushing is conducted; 4, the mixture obtained in the step 3 is added into the distillate or an essential oil mixture obtained in the step 2, sodium chloride or a sodium chloride solution is added, and the pH is adjusted for later use; 5, liquid medicine in the step 4 is poured into a plastic pre-filled injector or a glass pre-filled injector after sterilization, a push rod piston is used for sealing, and labeling and plastic packaging are conducted after sterilization is conducted through ethylene oxide.
Description
technical field [0001] The invention belongs to new dosage forms of traditional Chinese medicine injections, in particular to a pre-filled preparation of clinical emergency Chinese medicine injections. Background technique [0002] At present, the packaging of water injections for clinical use in China is almost all in ampoule packaging. When using, the neck of the glass ampoule needs to be cut, and then inhaled into a sterile syringe, injected into the patient or added to the infusion bottle for intravenous drip, intramuscular injection, etc. , there will inevitably be the risk of secondary pollution such as glass debris entering the liquid medicine and stabbing the operator's fingers. [0003] Pre-filled syringes are a new form of pharmaceutical packaging developed abroad. Pre-filled syringes are mainly used for packaging and storage of high-grade drugs and are directly used for injection or flushing in ophthalmology, ear, orthopedics and other operations. [0004] The p...
Claims
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Application Information
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