Azaspirone drug injection and its preparation method and application

Abstract

An azaspironone drug injection and a preparation method and application thereof, characterized in that the azaspironone drug injection comprises an active component of tandospirenone and a stabilizer. Described azapirone drug injection has high stability, good anti-anxiety effect, can meet the needs of clinical patients, can effectively solve children, or have digestive system disorders, or be in coma, convulsions, convulsions and other states and patients with dysphagia ( Such as elderly patients, bedridden patients) should not take tandospirone tablets or capsules orally. The azaspipirone drug injection also has the advantages of low cost, convenient use and the like. The solution of the azaspipirone drug injection is clear, the insoluble particles meet the standard, and the stability is good; there is no visible foreign matter and no abnormal toxicity; and its concentration does not cause toxicity and obvious irritation.

Description

technical field

[0001] The invention relates to an azaspirone drug injection, a preparation method and application thereof. Background technique

[0002] Anxiety is the most common emotional reaction and a central symptom of all neuroses. With the development of society and the accelerated pace of life, people's demand for anti-anxiety drugs is increasing day by day. The first-generation anti-anxiety drugs represented by meprobamate have poor drug resistance and severe withdrawal symptoms, and the second-generation anti-anxiety drugs of benzodiazepines have psychomotor dysfunction such as muscle relaxation, spasm, and spontaneous movement , memory discrimination dysfunction, psychological and physical dependence and other problems. The third-generation anti-anxiety drugs represented by tandospirone selectively act on the 5-HT1A receptors in the brain, and the action sites are concentrated in the hippocampus, amygdala and other brain limbic systems in the emotional center a...

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