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Application of glucoside-like compound in preparing drugs for preventing and curing diabetic complication

A compound and glycoside technology, applied in the field of medicine, can solve the problems that complications cannot be controlled accordingly, the etiology and pathogenesis are not very clear, etc., to reduce retinal ganglion cell layer degeneration, protect kidneys, and reduce UREA and CREA. horizontal effect

Active Publication Date: 2018-10-16
CHENGDU SINNOCEAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The etiology and pathogenesis of microvascular diseases such as diabetic retinopathy and nephropathy are not very clear at present. They are usually caused by a variety of risk factors and are irreversible. Blood sugar is effectively controlled, but complications cannot be controlled accordingly

Method used

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  • Application of glucoside-like compound in preparing drugs for preventing and curing diabetic complication
  • Application of glucoside-like compound in preparing drugs for preventing and curing diabetic complication
  • Application of glucoside-like compound in preparing drugs for preventing and curing diabetic complication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Measured the research experiment of H2 (being (IV) formula compound) to spontaneous type 2 diabetes db / db mouse therapeutic effect, concrete test and result are as follows:

[0044] 1. The compound can be reported in the literature "Isolation and Identification of Chemical Components of Coptis Rhizoma Water Extract" (Li Xuegai et al., Journal of Shenyang Pharmaceutical University, March 2012, Volume 29, No. 3, Pages 193-198) The preparation method of compound 15 was obtained.

[0045] 2. The regulations followed by the test: "Measures for the Administration of Drug Registration" (State Food and Drug Administration Bureau Order No. 28, October 1, 2007); Bureau Order No. 2, September 1, 2003).

[0046] 1. Test materials

[0047] 1. Test product

[0048] Name or code: H2;

[0049] Source: Chengdu Zhongchuang Shuyang Biotechnology Co., Ltd. laboratory;

[0050] Properties: solid;

[0051] Storage conditions: ≤-15°C, airtight and dry storage;

[0052] Preparation meth...

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PUM

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Abstract

The invention discloses application of a glucoside-like compound in preparing drugs for preventing and curing diabetic complication. The compound has a certain trend of reducing the UREA and CREA level and relieving the proliferation degree of glomerular mesangial or mesangial cells, and has a certain effect of protecting kidney; meanwhile, the compound can prominently relieve the degeneration degree of the retinal ganglion cell layer, and it is proved that the compound has the effect of relieving degeneration of the animal retinal ganglion cell layer. Therefore the compound has a certain protection effect on kidney and retina of diabetic animals, and has good economic and social values.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a glycoside compound in the preparation of medicines for preventing and treating diabetic complications. Background technique [0002] With the development of society, the prevalence of Diabetes Mellitus (DM) has increased significantly, and it has become one of the important diseases affecting human health. Diabetes mellitus is a common endocrine and metabolic disease with protein and fat metabolism disorders as the main clinical manifestations caused by relative or absolute insufficiency of insulin secretion in the body, resulting in high blood sugar. According to the eighth edition of the global diabetes map released by the International Diabetes Federation (IDF), there were 425 million diabetics in the world in 2017, and it is estimated that there will be nearly 700 million diabetics in 2045. The symptomatic treatment of diabetes is to control the blood sugar index...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P3/10A61P13/12A61P27/02A23L33/125
CPCA61P3/10A61P13/12A61P27/02A23L33/125A61K31/7034A23V2002/00A23V2200/328
Inventor 杨成苏丹钟治晖
Owner CHENGDU SINNOCEAN BIOTECH CO LTD
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