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Noble dendrobium powder and application thereof

A technology of Dendrobium dendrobii and powder is applied to Dendrobium dendrobii and its application field, and can solve the problems such as the lack of clear regulations on the pulverized particle size of the dried Dendrobium dendrobium

Inactive Publication Date: 2018-10-19
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the processing of secondary products, there is no clear regulation on the crushed particle size of Dendrobium nobile dry product, and there is no relevant literature report on what particle size powder can be better absorbed and distributed in the human body.

Method used

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  • Noble dendrobium powder and application thereof
  • Noble dendrobium powder and application thereof
  • Noble dendrobium powder and application thereof

Examples

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Embodiment Construction

[0015] The present invention will be further explained below in conjunction with specific embodiments, but the specific embodiments do not limit the present invention in any way. Unless otherwise specified, the reagents and methods involved in the examples are those commonly used in the art.

[0016] 1 Materials and methods

[0017] 1.1 Instruments

[0018] Thermo Scientific Q Exactive quadrupole-electrostatic field orbitrap high-resolution mass spectrometry system, ThermoUltrmate 3000 ultra-high performance liquid chromatography system (Thermo Fisher, USA), Genius 1022 liquid nitrogen generator (PEAK, UK), Milli-Q ultrapure water System (Millipore, USA), XS205 electronic balance (METTLERTOLEDO, Switzerland), XW-80A vortex mixer (Haimen Qilin Bell Instrument Manufacturing Co., Ltd.), Microfuge 20R high-speed centrifuge (Beckman Coulter Co., Ltd., USA), STW-FT24 Ice Machine (Sanyo, Japan).

[0019] 1.2 Experimental animals

[0020] 14 male healthy SPF SD rats (production ce...

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Abstract

The present application discloses noble dendrobium powder having a particle size of 150 to 180 mu m. The content of dendrine selected as a detection object in rat plasma is determined by an ultra performance liquid chromatography-mass spectrometry (UPLC-MS) technique, and the absorption of the noble dendrobium powder of different particle sizes in vivo can be quantitatively evaluated. By combination of the pharmacokinetic study method of noble dendrobium in a rat body, the content of the dendrine in the rat plasma can be determined by the ultra performance liquid chromatography-mass spectrometry (UPLC-MS) technique, experiments find that compared with the SD rat orally administered with 0.8g / kg of noble dendrobium ultrafine powder (45mu m), the SD rat orally administered with 0.8g / kg of noble dendrobium fine powder (150-180mu m) has high noble dendrobium fine powder absorption rate, good noble dendrobium fine powder absorption effect and short noble dendrobium fine powder absorption time. Experiment results indicate that unlike other traditional Chinese medicines, the crushed particle size of the noble dendrobium powder is not the smaller, the better, the absorption effect of the noble dendrobium fine powder (150 mu m to 180 mu m) in the body is much stronger than that of the noble dendrobium ultrafine powder (45 mu m).

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicinal materials, in particular to a kind of Dendrobium chinensis and application thereof. Background technique [0002] The traditional Chinese medicine Dendrobium has the functions of nourishing yin and clearing heat, invigorating the stomach and promoting body fluid, moistening the lungs and relieving cough, improving eyesight and strengthening the body. It is clearly stipulated in the 2015 edition of the Chinese Pharmacopoeia that one of the medicinal plant sources of Dendrobium is Dendrobium nobile Lindl. Due to its medicinal effect, its market demand is expanding day by day. How to better develop and utilize the medicinal resource of Dendrobium candidum is one of the focuses of current pharmaceutical research. Dendrobium dendrobium on the existing market is mainly sold as primary products in fresh strips and Fengdou. In the processing of secondary products, the...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K36/8984A61K9/14A61P3/10A61P35/00A61P39/06A61P25/28A61P27/12
CPCA23V2002/00A61K9/14A61K36/8984A23L33/00A61P3/10A61P25/28A61P27/12A61P35/00A61P39/06A23V2200/30A23V2200/328A23V2200/308A23V2200/02A23V2200/322
Inventor 鲁艳柳何芋岐吴迪秦琳杜艺玫张一新
Owner ZUNYI MEDICAL UNIVERSITY
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