Application of peach blossom blood purifying pill compound preparation to preparation of drugs for curing chloasma and freckles

A technology of compound preparation, Qingxue pill, applied in the field of medicine

Inactive Publication Date: 2018-11-06
山东新宝医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Lin Chunsheng. The Effect of Taohong Qingxue Pill on SCL-90 Score in Vitiligo Patients with Qi Depression and Blood Stasis Type. World Traditional Chinese Medicine. Volume 7, Issue 3, May 2012.) However, it has not been used for chloasma , reports on the treatment of freckles

Method used

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  • Application of peach blossom blood purifying pill compound preparation to preparation of drugs for curing chloasma and freckles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation process of Taohong Qingxue Pill

[0027] Tribulus terrestris (fried) 37.83g

[0028] Comfrey 12.67g

[0029] Aromatherapy 12.67g

[0030] Ginseng 12.67g

[0031] Bai Wei 12.67g

[0032] Peach kernels (fried) 12.67g

[0033] Safflower 12.67g

[0034] Polygonum multiflorum 12.67g

[0035] Licorice 12.67g

[0036] Cangzhu (fried) 5g

[0037] Gentian 5g

[0038] Baiyaozi 12.67g

[0039] Sea octopus 6g

[0040] The first thirteen flavors, Tribulus terrestris were extracted twice with water, each time for 2 hours, concentrated, dried, and crushed, and the other twelve flavors were mixed and ground into fine powder, mixed with the above extracts, and made into 1000 concentrated water pills.

Embodiment 2

[0041] Example 2 Effect of Taohong Qingxue Pills on Mouse B16 Melanoma Cells

[0042] Mouse B16 melanoma cell line is a highly melanized melanoma cell line, which is often used in the research of melanin synthesis in the world. In this experiment, mouse B16 melanoma cells were cultured, the effects of different concentrations of Taohong Qingxue pills on cell proliferation were determined by MTT method, the effects on cell tyrosinase activity were determined by L-DOPA oxidation method, and the NaOH cracking method was used to detect Cell melanin content.

[0043] Effects of Taohong Qingxue Pills on Proliferation Rate, Cell Melanin Synthesis and Cell Tyrosinase Activity of B16 Cells

[0044]

[0045] Conclusion: The compound preparation of Taohong Qingxue Pills can significantly inhibit the synthesis of melanin in mouse B16 melanoma cells, but has no effect on the activity of tyrosinase, which shows that it has great potential in the treatment of pigmented skin diseases such...

Embodiment 3

[0046] Example 3 Observation on the Clinical Curative Effect of Taohong Qingxue Pills in Treating Female Chloasma

[0047] Materials and methods:

[0048] 1. General information: A total of 120 patients were enrolled, all of whom were female patients who came to the hospital from February to October 2012, and met the diagnostic criteria for melasma. The age of the patient is 27-46 years old; the course of disease is 2 months to 6 years. Among them, there were 72 cases of butterfly shape, 22 cases of upper face, 9 cases of lower face, and 17 cases of generalized type. Randomly divided into 2 groups. There was no significant difference in age, condition, course of disease and severity of skin lesions before treatment between the two groups, and they were comparable. The selected patients denied any history of long-term use of hormone drugs and retinoic acid drugs; blood, NIAO, urine routine, liver and kidney functions were normal before and after enrollment.

[0049] 2. Diag...

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Abstract

The invention discloses a new application of a peach blossom blood purifying pill compound preparation to preparation of drugs for curing chloasma and freckles. The experiment proves that the peach blossom blood purifying pill preparation can obviously inhibit synthesis of melanin of mouse B16 melanoma cells, while has no effect on the activation of tyramine oxidase, and the peach blossom blood purifying pill preparation has the good effect on treatment of pigmented dermatoses can be proved. Clinical research verifies that the peach blossom blood purifying pill preparation adopts vitamin E asa control group when being used for treating chloasma, the effect of the peach blossom blood purifying pill preparation on treating chloasma is obviously superior to the effect of taking vitamin drugsorally, and the peach blossom blood purifying pill preparation has the better safety. The clinic research verifies that when the peach blossom blood purifying pill preparation is used for treating freckles, oral taking vitamin E and externally applying hydroquinone are taken as the control group, the total effective rate is improved remarkably, and no obvious adverse drug reaction occurs. The above research proves that the application field of the peach blossom blood purifying pill to treatment of chloasma and freckles is developed, the new treatment drug is provided for the field of chloasmaand freckle skin diseases, and the peach blossom blood purifying pill compound preparation has the very good clinic research meaning.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular to the application of a compound preparation of Taohong Qingxue Pills in the preparation of medicines for chloasma and freckles, and belongs to the technical field of medicine. Background technique [0002] Chloasma and freckles are easily diagnosed and refractory skin diseases mainly characterized by facial pigmentation. Traditional Chinese medicine believes that the etiology and pathogenesis of chloasma and freckles are relatively complicated. The overall view of traditional Chinese medicine believes that skin diseases are the external manifestations of human viscera, qi and blood, meridians, and disharmony between camp and health. According to the ancients, the five colors belong to the five internal organs. In addition, the pathogenesis of this disease is the disharmony of qi and blood, and the design of blood stasis and blood deficiency leads to blood stagnation in the meridia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/20A61P17/00A61K35/618
CPCA61K9/20A61K35/618A61K36/185A61K36/27A61K36/284A61K36/286A61K36/30A61K36/48A61K36/484A61K36/515A61K36/59A61K36/704A61K36/736A61P17/00A61K2300/00
Inventor 王浩骅孙爱菊王庆生郑荣先徐中利代伟王兰法郭志强荆进红任军民高恒忠马全龙
Owner 山东新宝医药有限公司
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