Novel preparation method of 4-methoxyl-beta-nitrostyrolene

A technology of nitrostyrene and p-methoxybenzaldehyde, which is applied in the field of medicine and can solve problems such as complex synthesis process, low yield, and unstable yield

Inactive Publication Date: 2018-11-23
SHANGHAI HUAJIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The yield of the existing 4-methoxy-β-nitrostyrene preparation method is not high, the synthesis process is complicated, and the yield is unstable. It is necessary to invent a new preparation method to overcome the deficiencies of the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: Preparation of 4-methoxy-β-nitrostyrene:

[0008] Add 1362 mg of p-methoxybenzaldehyde in the reactor, add 30 ml of methanol, stir, add 671 mg of nitromethane at room temperature, then stir in an ice bath for 20 minutes, then add 848 mg of ammonium acetate, and then stir at room temperature After 4 hours, the reaction solution gradually turned yellow. After standing for 5 hours, the yellow solid was filtered off. Then recrystallized in methanol, filtered and dried in vacuum to obtain the compound 4-methoxy-β-nitrostyrene with a yield of 92.3%.

Embodiment 2

[0009] Embodiment 2: Preparation of 4-methoxy-β-nitrostyrene:

[0010] Add 1362 mg of p-methoxybenzaldehyde in the reactor, add 30 ml of methanol, stir, add 671 mg of nitromethane at room temperature, then stir in an ice bath for 20 minutes, then add 848 mg of ammonium acetate, and then stir at room temperature After 4 hours, the reaction solution gradually turned yellow. After standing for 5 hours, the yellow solid was filtered off. Then recrystallize in methanol, filter and dry in vacuum to obtain the compound 4-methoxy-β-nitrostyrene with a yield of 93.1%.

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PUM

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Abstract

The invention relates to a novel preparation method of 4-methoxyl-beta-nitrostyrolene, belonging to the technical field of medical technologies. The technical problem solved by the invention is relevant to a more advanced novel preparation method of the 4-methoxyl-beta-nitrostyrolene. The key point of the technical scheme for the technical problem solved in the invention is the novel preparation method of a compound. The formula is shown in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a new preparation method of 4-methoxy-β-nitrostyrene. Background technique [0002] 4-Methoxy-β-nitrostyrene is an important intermediate raw material for the synthesis of pharmaceutical products. [0003] The yield of the existing 4-methoxy-β-nitrostyrene is not high, the synthesis process is complicated, and the yield is unstable. It is necessary to invent a new preparation method to overcome the shortcomings of the prior art. Contents of the invention [0004] The present invention adopts a new technology, aiming at the disadvantages of the existing 4-methoxy-β-nitrostyrene preparation method that the yield is not high, the synthesis process is complex, the yield is unstable, and the purchase cost of the required raw materials is high. , after long-term research and development, a new preparation method was invented to overcome the shortcomings of th...

Claims

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Application Information

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IPC IPC(8): C07C201/12C07C205/32
CPCC07C201/12C07C205/32
Inventor 不公告发明人
Owner SHANGHAI HUAJIN BIOTECH CO LTD
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