A method for measuring tms motor threshold in awake rats

A wake-up state, motion threshold technology, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of large differences in the maximum output of magnetic stimulators, lack of individuality, and difficult comparison of research results

Active Publication Date: 2021-05-25
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0003] In the current TMS rat research, some use the percentage of the maximum output of the magnetic stimulator as the TMS stimulation intensity, which lacks individuality, and the maximum output of different magnetic stimulators varies greatly, which makes it difficult to compare the results of different studies

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  • A method for measuring tms motor threshold in awake rats
  • A method for measuring tms motor threshold in awake rats

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Embodiment Construction

[0028] A method for measuring the TMS motor threshold in rats in an awake state of the present invention will be described in detail below with reference to the embodiments and accompanying drawings.

[0029] A method for measuring the TMS motor threshold in rats in an awake state of the present invention, first adopts the mode of inhalation gas anesthesia to temporarily anesthetize the rats; secondly, the rats are restrained and fixed on the bracket by self-adhesive bandages, and the height of the bracket is greater than The length of the rat limbs (including forelimbs and hindlimbs), the rat limbs are suspended in the air and kept in a relaxed state; then the hair is shaved around the target muscle, and the surface electromyography measurement electrode and the ground electrode are respectively pasted on the target muscle and tail of the rat limb ; Finally, the TMS pulse is applied to the motor cortex of the rat, and the measurement of the TMS movement threshold of the rat in...

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Abstract

A method for measuring the TMS motor threshold in rats in an awake state, comprising: anesthetizing the rats for 2-3 minutes by means of inhalation gas anesthesia; The restraint is fixed on the bracket, the height of the bracket is greater than the length of the front and rear limbs of the rat, so that the rat limbs are suspended in the air and kept in a relaxed state; the hair around the target muscles of the rat limbs is shaved to expose the belly and tendon of the target muscles, and the surface EMG is pasted. Measuring electrodes and grounding electrodes; TMS pulses are applied to the motor cortex of rats in an awake state, and TMS in an awake state of rats is completed by observing the twitching of the rat limbs or by analyzing the motor-evoked potentials in the surface electromyographic signals of the target muscles Measurement of motor threshold. The invention can measure the TMS movement threshold of the rat in the awake state. Compared with the TMS motor threshold under anesthesia, the TMS motor threshold in the awake state is more helpful to accurately set the TMS stimulation intensity in the rat TMS experiment.

Description

technical field [0001] The invention relates to a method for measuring the TMS motor threshold of rats. In particular, it relates to a method for measuring TMS motor threshold in awake rats. Background technique [0002] Transcranial magnetic stimulation (TMS) technology is a technology that uses time-varying pulsed magnetic fields to act on the central nervous system (mainly the brain), changing the membrane potential of cortical nerve cells, causing them to generate induced currents, and affecting brain metabolism. And nerve electrical activity, thereby triggering a series of physiological and biochemical responses of magnetic stimulation technology. TMS mainly has four stimulation parameters: intensity, frequency, string stimulation time, and interval between strings. Among them, the TMS stimulation intensity refers to the magnetic induction intensity generated on the surface of the stimulation coil during operation, which represents the stimulation energy given by the ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/398A61B5/00
CPCA61B5/4827A61B5/389
Inventor 殷涛王欣刘志朋王腾飞
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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