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Chemically modified electrode for sensitive detection of doxycycline as well as preparation method and application thereof

A chemical modification, doxycycline technology, applied in the field of electroanalytical chemistry and electrochemical sensors, can solve the problems of limited doxycycline detection applications, complex sample pretreatment, expensive instruments and equipment, etc., to achieve good accuracy and good selectivity , the effect of low cost

Active Publication Date: 2019-01-01
XINYANG NORMAL UNIVERSITY
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  • Description
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Problems solved by technology

However, the above methods require complex sample pretreatment, expensive instruments and cumbersome operations, which limit the practical application of doxycycline detection.

Method used

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  • Chemically modified electrode for sensitive detection of doxycycline as well as preparation method and application thereof
  • Chemically modified electrode for sensitive detection of doxycycline as well as preparation method and application thereof
  • Chemically modified electrode for sensitive detection of doxycycline as well as preparation method and application thereof

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Embodiment Construction

[0033] Below in conjunction with accompanying drawing, the present invention will be further described:

[0034] The modified electrode is ZnIn 2 S 4 @In 2 o 3 The glassy carbon electrode modified by @MXene nanocomposite is prepared as follows:

[0035] Step 1. ZnIn 2 S 4 @In 2 o 3 Preparation of @MXene nanocomposites:

[0036] Synthesis of In-MIL-68 prisms: 60 mg In(NO 3 ) 3 ·xH 2 O and 60 mg terephthalic acid were dissolved in 40 mL DMF and stirred for 2 min. Then the resulting solution was placed in an oil bath at 120°C and stirred and heated for 30 min. After cooling to room temperature, the centrifuged white precipitate was washed 5 times with ethanol, and vacuum-dried overnight at 40°C;

[0037] Hexagon In 2 o 3 Synthesis of microtubes: Calcining the obtained In-MIL-68 prisms at a heating rate of 5 °C / min to 120 °C for 2 h, and then continuing to calcine at the same heating rate to 500 °C for 2 h ;

[0038] Sandwich ZnIn 2 S 4 @In 2 o 3 Preparation of...

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Abstract

The invention discloses a chemically modified electrode for sensitive detection of doxycycline as well as a preparation method and application thereof. The modified electrode is a glassy carbon electrode with high electrical activity and modified by ZnIn2S4@In2O3@MXene nanocomposite. The invention relates to the field of electroanalytical chemistry and electrochemical sensors. The ZnIn2S4@In2O3@MXene graded tubular heterojunction nanocomposite disclosed by the invention has large specific surface area and high catalytic activity and can increase the enrichment amount of doxycycline in an electrochemical detection medium and improve the measurement sensitivity while effectively accelerating electron transfer and improve the electrochemical response signal; and the composite has the advantages of high selectivity, simplicity and convenience, low price and high stability and is suitable for field detection. The chemically modified electrode prepared by the invention is already successfully applied to the accurate detection of doxycycline in animal-derived food.

Description

technical field [0001] The invention relates to the fields of electroanalytical chemistry and electrochemical sensors, in particular to a chemically modified electrode for sensitive detection of doxycycline, a preparation method and application thereof. Background technique [0002] Doxycycline is a tetracycline antibiotic widely used in the treatment of Chlamydia mycoplasma infections such as chronic prostatitis, respiratory tract infections, sinusitis and sexually transmitted diseases. Due to its broad antibacterial capabilities, doxycycline is also used in agriculture, forestry, animal husbandry, and aquaculture as a fertilizer or animal food additive. However, excessive use of doxycycline can lead to serious environmental and food contamination, pose considerable risks to human health, especially to children, and may lead to drug resistance of bacteria, long-term and repeated intake of doxycycline will also Affects the growth and formation of teeth. Doxycycline residue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 孙俊永甘甜李洁彬徐力萍刘彦明
Owner XINYANG NORMAL UNIVERSITY
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