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Blood sample analysis method and system, for determining diabetes

A technology of a blood analysis system and an analysis method, which is applied in the field of sample analysis systems and can solve problems such as unconfirmed changes in other amino acids

Inactive Publication Date: 2019-01-04
OSAKA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

In Patent Document 5, changes in D-amino acids and L-amino acids in diabetic patients were studied, but it was confirmed that among these 40 kinds of chiral amino acids, D-alanine, L-cysteine, and L-glutamine Acids fluctuate in diabetics, on the other hand, no other amino acid shifts identified

Method used

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  • Blood sample analysis method and system, for determining diabetes
  • Blood sample analysis method and system, for determining diabetes
  • Blood sample analysis method and system, for determining diabetes

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Embodiment

[0122] Analysis of Groups and Samples

[0123] From August 2005 to January 2009, the inventors of the present invention recruited 118 patients with CKD stage 3, stage 4, and stage 5 who were not receiving dialysis from the first nephrology department of Rinku General Medical Center (Rinku General Medical Center) Consecutive patients were registered to the prospective survey. After fasting overnight, a baseline blood sample was obtained from the patient, and it was put into a plastic tube to prepare plasma. Patients from whom only insufficient blood samples could be obtained were excluded first.

[0124] This experiment was approved by the Ethics Committee of Rinku General Medical Center and was conducted based on the Declaration of Helsinki.

[0125] Inclusion criteria for baseline were set at age less than 90 years, no complications related to malignancy, and no infection to infectious diseases. Patients who could only obtain incomplete baseline data (n = 2) or patients ...

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Abstract

The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.

Description

technical field [0001] The present invention relates to a blood sample analysis method for determining diabetes based on the amount of D-type and L-type amino acids from a blood sample, a method for examining diabetes, and a sample analysis system for outputting pathological information about diabetes. Background technique [0002] Diabetes is a metabolic disorder characterized by hyperglycemia, and is broadly classified into type 1 and type 2 diabetes. It is known that type 1 diabetes is a disease in which β cells are selectively destroyed due to the induction of immune response by genetic factors and viral infection. Usually, it occurs due to autoimmunity, and occasionally it occurs suddenly. Type 2 diabetes is diabetes caused by both decreased insulin secretion and decreased sensitivity. Type 2 diabetes is classified as a lifestyle-related disease, and its cause has not been fully elucidated. It is considered that people who are genetically predisposed to diabetes (gene...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6812G01N2800/042G01N2800/7042G01N33/6893G01N33/68
Inventor 猪阪善隆木村友则安田圭子浜濑健司三田真史
Owner OSAKA UNIV
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