Anti-ulcerative colitis granule and preparation method

A colitis and anti-ulcer technology, applied in the field of medicine

Inactive Publication Date: 2019-01-08
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, there is no medicine or pharmaceutical composition

Method used

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  • Anti-ulcerative colitis granule and preparation method
  • Anti-ulcerative colitis granule and preparation method

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preparation example Construction

[0030] Meanwhile, the present invention also provides a kind of preparation method of anti-ulcerative colitis granule, the method comprises the following steps:

[0031] 1) Weigh purslane and cinnamon according to the weight ratio of 10-14:3-7 and mix the purslane and cinnamon to obtain a mixture. The weight ratio of purslane and cinnamon is preferably 11-12:4-5 2) Add water to the mixture obtained in step 1), extract at a temperature of 60°C-100°C (preferably 90°C) for 1-6h (preferably 5h), filter the dregs, and concentrate to a thick extract; the mixture is mixed with The solid-liquid ratio of water is 1:10-50, preferably 1:40;

[0032] 3) Place the thick extract prepared in step 2) in a -80°C refrigerator for no less than 24 hours, take it out and dry it in a freeze dryer for 24 hours, and grind it into a fine powder after completion;

[0033] 4) Mix the fine powder prepared in step 3) with sucrose; the weight ratio of the fine powder to sucrose is 1:2-5, preferably not le...

Embodiment 1

[0088] Weigh 200.0g of purslane, 83.3g of cinnamon, add 30 times the amount of water, extract at 90°C for 5h, filter the dregs, concentrate to a thick extract, and obtain 63.6g, which is equivalent to 21.3g / 100g of the original medicinal material. Place it in a -80°C refrigerator for 24 hours, then dry it in a freeze dryer for 24 hours, take it out, grind it into a fine powder, and obtain 43.1 g of cream powder, which is set aside. Extract again, concentrate to a thick extract, 4 times, and save the thick extract.

[0089] Weigh the cream powder and sucrose and mix evenly in a ratio of 1:2, add 80% ethanol solution to adjust the humidity, and make a soft material that "kneads into a ball by hand and disperses when lightly pressed". Then pass through No. 1 drug sieve to make granules by extrusion granulation. Put it in the oven to dry in time. After drying, it will be partially agglomerated and sticky, and it will be ground and pressed. Use No. 1 sieve to remove coarse partic...

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Abstract

The invention belongs to the field of medicines, and relates to an anti-ulcerative colitis granule and a preparation method. The anti-ulcerative colitis granule is prepared from purslane and cassia bark, wherein the initial weight ratio of purslane to cassia bark is (10-14):(3-7). The invention provides the anti-ulcerative colitis granule which is simple in preparation technology, has no toxic orside effects and can be used for treating ulcerative colitis and the preparation method of the granule.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a granule and a preparation method, in particular to an anti-ulcerative colitis granule and a preparation method. Background technique [0002] Ulcerative colitis (UC) is a nonspecific inflammatory disease involving the mucosa and submucosa of the large intestine and rectum. In exceptional cases, defined as colitis, the entire large intestine may be affected. The clinical manifestations are mainly abdominal pain, diarrhea, mucus, pus and blood in the stool, etc. Endoscopically, the colon shows diffuse inflammation such as erosion and ulcer. Research reports have shown that the occurrence of UC is closely related to the imbalance of anti-inflammatory factors and pro-inflammatory factors in the body. The abnormal increase of inflammatory cytokines or the abnormal decrease of anti-inflammatory cytokines can promote the changes of intestinal mucosal inflammation, and the persistent imbalance o...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/16A61P1/04A61P31/04A61P29/00
CPCA61K9/1623A61K36/185A61K36/54A61K2236/331A61K2236/51A61P1/04A61P29/00A61P31/04A61K2300/00
Inventor 王征唐志书梁艳妮刘力宋忠兴
Owner SHAANXI UNIV OF CHINESE MEDICINE
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