A rat spinal cord signal detection and evaluation system and method

Abstract

The invention discloses a rat spinal cord nerve signal detection and evaluation system and method, comprising a stimulating electrode, a recording electrode, a pulse stimulator and a nerve signal acquisition system, the stimulating electrode is connected to the pulse stimulator, and the recording electrode is connected to the nerve signal acquisition system. The invention uses electronic detection methods to perform functional electrical stimulation on the primary motor cortex of the rat brain, records the spinal cord nerve signals corresponding to the T9‑T12 segment of the spine and the coordinates of the corresponding sites, and detects the rat brain from the two indicators of correlation coefficient and delay time. The motor cortex controls the conduction pathway of the nerves that control the movement of the lower limbs in the spinal cord. The results show that there is a high correlation coefficient between the signals recorded at the effective sites, and there is a certain delay. The invention can provide practical data for the implantation of detecting electrodes in the microelectronic nerve bridge experiment, detect and evaluate the conduction function of the rat spinal cord from the perspective of electronic information, and prove the feasibility of the microelectronic nerve bridge experiment at the animal experiment level.

Description

technical field [0001] The invention relates to the technical field of nerve signal detection and evaluation, in particular to a rat spinal cord nerve signal detection and evaluation system and method. Background technique [0002] The spinal cord is a part of the central nervous system of humans and vertebrates. In the spinal canal, the upper end is connected to the medulla oblongata, and paired nerves are sent out from both sides, which are distributed to the limbs, body wall and internal organs. Inside the spinal cord there is an H-shaped (butterfly-shaped) gray matter area, mainly composed of nerve cells; around the gray matter area is a white matter area, mainly composed of myelinated nerve fibers. The spinal cord is the center of many simple reflexes. On both sides of the spinal cord send out many pairs of nerves (called spinal nerves) that distribute to the skin, muscles and internal organs throughout the body. The spinal cord is the pathway between the peripheral n...

AI Technical Summary

Problems solved by technology

Scholars have tried to achieve the goal of curing spinal cord injury through stem cell transplantation, bionic scaffold materials, and elimination of nerve growth inhibitory factors. Although some results have been achieved, there are many unfavorable factors and technical difficulties in treatment.

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