A nanopore functional control method and system

A control system and nanopore technology, applied in the direction of nanotechnology, material electrochemical variables, etc., can solve the problems of difficult manufacturing reproducibility, short service life of nanopores, and inability to reuse, so as to save time, improve efficiency, and reduce manpower The effect of resource input

Active Publication Date: 2021-04-13
GUANGDONG UNIV OF EDUCATION
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  • Abstract
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  • Claims
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Problems solved by technology

[0003] To sum up, the existing problems in the existing technology are: the cost of preparing solid-state nanopores is high, the manufacturing reproducibility is difficult, the service life of nanopores is short and cannot be reused, and the control of functionality cannot be realized. Unable to meet the needs of researchers

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  • A nanopore functional control method and system
  • A nanopore functional control method and system
  • A nanopore functional control method and system

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Embodiment Construction

[0052] In order to further understand the content, features and effects of the present invention, the following examples are given, and detailed descriptions are given below with reference to the accompanying drawings.

[0053] The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0054] Such as figure 1 As shown, the nanopore functional control system described in the embodiment of the present invention includes: a nanopore preparation module 1, a molecular construction module 2, a molecular construction solution preparation module 3, a potential application module 4, an ion current measurement module 5, and an ion current acquisition module. Module 6 , computer central processing unit module 7 , ion current data processing module 8 , construct removal module 9 , microfluid flushing module 10 , construct collection module 11 , and antibody collection module 12 .

[0055] A nanopore preparation module 1, the ...

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Abstract

The invention belongs to the technical field of nanopore functionality, and discloses a nanopore functional control method and system. Nanopores are manufactured through a nanopore preparation module, and a molecular construction solution is prepared through a molecular construction solution preparation module. A solution of a construct is introduced to the substrate, the molecular construct having a body structure defining a pore and tail structures extending from the body structure. In the present invention, the molecular construct is docked onto the substrate by applying a potential difference across the substrate through a pair of potential application modules to cause the tail structure to pass through the nanopore, wherein the hole is paired with the nanopore aligning; and removing the molecular construct from the substrate by changing the potential difference through a potential applying module.

Description

technical field [0001] The invention belongs to the technical field of nanopore functionality, and in particular relates to a nanopore functional control method and system. Background technique [0002] Currently, single nanopores in insulating layers are under investigation as single-molecule sensors in solution1. Research activity in nanopore sensing has grown rapidly since the first experiments on DNA and RNA translocation by Kasianowicz et al. Single solid-state nanopores fabricated by silicon nanotechnology and ion milling have been applied for the first time in ionic current-based DNA detection. DNA folding detection using nanocapillaries, development of selective fabrication schemes such as transmission-electron drilling of solid-state nanopores, or nanopores with other single-molecule technologies such as optical tweezers, magnetic tweezers or single-molecule fluorescence, has given new impetus to the field. In a typical application, the nanopore separates two cha...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26B82Y40/00
CPCB82Y40/00G01N27/26
Inventor 周仁龙杨飒周桓君肖鹰翼刘丹
Owner GUANGDONG UNIV OF EDUCATION
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