Novel application of Danhong blood stasis dispersing composition

A technology of Danhong removing blood stasis and composition, which is applied in the application field of Danhong removing blood stasis composition as a histone deacetylase agonist, and achieves the effects of fast onset time and exact effect.

Inactive Publication Date: 2019-01-29
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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  • Novel application of Danhong blood stasis dispersing composition
  • Novel application of Danhong blood stasis dispersing composition
  • Novel application of Danhong blood stasis dispersing composition

Examples

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Example Embodiment

[0028] Example 1: Study on the effect of DHK in regulating SIRT1 / NF-κB signaling pathway

[0029] 1. Experimental animals: SPF grade SD rats; half male and half male; 30 in total; 250-280g

[0030] 2. Experimental drugs and instruments:

[0031] Physiological saline (Foshan Shuanghe Pharmaceutical Co., Ltd.), Xylazine injection (Jilin Huamu Animal Health Products Co., Ltd.), Pentobarbital Sodium (German Merck), Ceftriaxone Sodium for Injection (Shenzhen Li Jian Pharmaceutical Co., Ltd.), 2% lidocaine hydrochloride (Hubei Tianyao Pharmaceutical Co., Ltd.), rat CRP ELISA kit (Nanjing Jiancheng Company), rat IL-1β ELISA kit (U.S. eBioscience company), rat TNF-α ELISA kit (Lianke Biotechnology Co., Ltd.), rat PAI-1 ELISA kit (British Abcam), rat tPA ELISA kit (British Abcam), BCA protein detection kit (Comverse Century Co., Ltd.) , Anti-SIRT1 antibody (abcam company), Anti-Akt antibody (CST company), Anti-p-Akt antibody (CST company), Anti-p65 antibody (CST company), Anti-p-p65 antibod...

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Abstract

The invention discloses application of a Danhong blood stasis dispersing composition as a silent mating type information regulation 2 homolog 1 (SIRT1) agonist. The Danhong blood stasis dispersing composition comprises seven traditional Chinese medicines of salvia miltiorrhiza, Chinese angelica, ligusticum wallichii, peach kernel, safflower, bupleurum root and bitter orange. As the SIRT1 agonist,the Danhong blood stasis dispersing composition can regulate the expression of SIRT1 protein in blood vessels and play a key role in the prevention and treatment of related diseases. In particular, the Danhong blood stasis dispersing composition has fast onset time and definite effect, and can be used for early prevention of venous embolic diseases.

Description

Technical field: [0001] The invention relates to a new application of Danhong Huayu formula, in particular to the application of Danhong Huayu composition as a histone deacetylase agonist. Background technique: [0002] SIRT1 (silent mating type information regulation 2 homolog 1) is a histone deacetylase dependent on nicotinamide adenine dinucleotide, its physiological role is very complex, related to cell aging, life extension, anti-oxidative stress and energy It is related to various functional activities of cells such as metabolic regulation. The substrates of SIRT1 include histones (K26 of histone H1, K9 of histone H3 and K16 of histone H4) and non-histone proteins (involved in apoptosis, neuron protection, organ metabolic function, cell senescence and tumorigenesis, etc. ) and various transcription factors. SIRT1 protein consists of 500 amino acid residues, and the relative molecular weight of the translated protein is about 60kD. [0003] Danhong Huayu Oral Liquid ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P9/14A61P7/02A61P29/00
CPCA61K36/232A61K36/233A61K36/236A61K36/286A61K36/537A61K36/736A61K36/752A61P7/02A61P9/14A61P29/00A61K2300/00
Inventor 林娟林宝琴王德勤李楚源张一凡覃仁安
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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