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A drug coating composition for ureteral stent and its preparation method and application

A technology of drug coating and ureter, which is applied in the field of medical devices, can solve the problems of uneven control of drug release and poor curative effect, and achieve the effect of treating ureteral injury, lasting curative effect, smooth release and absorption

Active Publication Date: 2021-01-29
PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method also has the defect that the drug release cannot be uniformly controlled, and the curative effect is poor

Method used

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  • A drug coating composition for ureteral stent and its preparation method and application
  • A drug coating composition for ureteral stent and its preparation method and application
  • A drug coating composition for ureteral stent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The drug coating composition provided by this embodiment includes the following components in parts by weight

[0072]

[0073] Dissolve rapamycin, puerarin, formoterol, dexamethasone, mallow seeds, light bamboo leaves, imperata root and plantain seed (the mass ratio of the four natural products is the same) in water according to the proportion, and then mix the Proportional amounts of polyvinylpyrrolidone and sorbitol are added to water, mixed and stirred at 50° C. to form a uniform mixed solution to obtain a drug coating composition.

Embodiment 2

[0075] The drug coating composition provided by this embodiment includes the following components in parts by weight

[0076]

[0077] Rapamycin, puerarin, formoterol, triclosan, mallow seed, light bamboo leaf and sea gold sand (three kinds of natural products with the same mass ratio) were dissolved in ethanol according to the ratio, and then the ratio of poly Add vinylpyrrolidone and xylitol to ethanol, mix and stir at 60° C. to form a uniform mixed solution to obtain a drug coating composition.

Embodiment 3

[0079] The drug coating composition provided by this embodiment includes the following components in parts by weight

[0080]

[0081]

[0082] Dissolve rapamycin, puerarin, formoterol, rifampicin, dendrobium, light bamboo leaf and Haijinsha (three kinds of natural products with the same mass ratio) in isopropanol according to the ratio, and then the ratio of poly Add oxyethylene sorbitan monostearate and xylitol into isopropanol, mix and stir at 40° C. to form a uniform mixed solution to obtain a drug coating composition.

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Abstract

The invention provides a drug coating composition for ureteral stents and its preparation method and application; the drug coating composition comprises the following components in parts by weight: 0.3-1.3 parts of rapamycin, puerarin 0.02-0.09 parts, 0.01-0.05 parts of formoterol, 0.2-1.5 parts of anti-infective drugs, 2-6 parts of natural products, 1-2 parts of hydrophilic polymers, 1.3-4.5 parts of additives, 20-90 parts of solvents; The drug coating composition provided by the present invention not only has a good effect of dilating the ureter, but also has antibacterial and anti-inflammatory properties, and can treat ureteral injury through the reasonable combination of the three components of rapamycin, puerarin and anti-infective drugs. At the same time, through the adjustment of hydrophilic polymers and additives, the composition has a long-acting sustained-release effect and achieves a more durable curative effect. It also provides a new strategy for the research and development of new drugs and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a drug coating composition for ureteral stents, a preparation method and application thereof. Background technique [0002] The drug coating on the stent is to coat the drug directly or mixed with the polymer matrix on the surface of the stent, so that the stent becomes a local drug release system, which can increase the local concentration and action time of the therapeutic drug on the one hand, and on the other hand Toxic and side effects caused by systemic administration can be avoided. [0003] According to clinical statistics, ureteral stenosis is a common long-term complication after ureteral calculus surgery. Whether it is open stone removal, laparoscopic stone removal, or endoscopic lithotripsy, the incidence of ureteral stricture is about 10%. With the development of endourology, the incidence of surgery-induced ureteral injury has increased significantly. The ureter injur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/436A61K31/137A61K31/63A61K31/496A61K31/573A61K31/155A61K31/075A61K31/165A61P13/02A61P31/02A61P31/04A61P29/00A61K36/899A61K35/57
CPCA61F2/82A61F2310/0097A61K31/075A61K31/137A61K31/155A61K31/165A61K31/352A61K31/436A61K31/496A61K31/573A61K31/63A61K35/57A61K36/12A61K36/185A61K36/68A61K36/8984A61K36/899A61P13/02A61P29/00A61P31/02A61P31/04A61K2300/00
Inventor 夏佩佩魏征谢建
Owner PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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