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Use of parabacteroides goldsteinii to treat fatty liver disease

A technology of parabacteroides and fatty liver, applied in the field of parabacteroides gordii, can solve the problems of bacterial flora change, unclear symptoms and progress, etc., and achieve the effect of weight loss

Active Publication Date: 2019-03-05
CHANG GUNG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In patients with fatty liver disease, gut dysbiosis has been found, but it is still unclear whether the use of prebiotics or probiotics to modify the composition of the gut microbiota can alleviate the symptoms and symptoms of the disease. progress

Method used

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  • Use of parabacteroides goldsteinii to treat fatty liver disease
  • Use of parabacteroides goldsteinii to treat fatty liver disease
  • Use of parabacteroides goldsteinii to treat fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Effect of Parabacteroides gordii on the content of aspartate aminotransferase in the blood of obese mice induced by high-fat diet

[0025] First, 8-week-old C57BL / 6Narl male mice were divided into normal diet mice fed a standard diet (energy source 13.5% fat; LabDiet 5001, LabDiet, the United States) as a control group, and fed a high-fat diet (energy source 60% % is fat; TestDiet 58Y1, TestDiet, USA) high-fat diet mice were used as the experimental group. Each group was given 200 μl of Parabacteroides gordii ATCC BAA-1180 strain (2×10 6 CFUs) or phosphate buffered saline for 8 weeks (n=10, representing 10 mice in each group). The aforementioned groups of mice are marked as normal diet mice+phosphate buffer saline, normal diet mice+P.goldsteini, high-fat diet mice+phosphate buffer saline, and high-fat diet mice+P.goldsteini.

[0026] After feeding for 8 weeks, detect the aspartate aminotransferase content in the blood of every group of mice with biochemical ...

Embodiment 2

[0028] Example 2 Effect of Parabacteroides gordii on liver weight of obese mice induced by high-fat diet

[0029] Prepare 8-week-old C57BL / 6Narl male mice as in Example 1 above, divide them into groups and feed them, and each group is also normal diet rats+phosphate buffer saline, normal diet rats+P.goldsteini, high-fat diet rats+phosphoric acid Saline buffer, and high-fat diet mice+P.goldsteini.

[0030] After feeding for 8 weeks, the livers of mice in each group were taken out and weighed, and the results were as follows: figure 2 shown. The data of the experimental results are shown as the mean ± standard deviation, and statistical analysis was performed with one-way ANOVA and Bonferroni post hoc test (**<0.01).

[0031] See figure 2 , figure 2It is a graph showing the effect of Parabacteroides gordii in the embodiment of the present invention on the liver weight of obese mice with normal diet and high-fat diet. It can be seen from the figure that compared with the ...

Embodiment 3

[0032] Example 3 Effect of Parabacteroides gordii on Fat Accumulation in Obese Mice Induced by High Fat Diet

[0033] Prepare 8-week-old C57BL / 6Narl male mice as in Example 1 above, divide them into groups and feed them, and each group is also normal diet rats+phosphate buffer saline, normal diet rats+P.goldsteini, high-fat diet rats+phosphoric acid Saline buffer, and high-fat diet mice+P.goldsteini.

[0034] After feeding for 8 weeks, the livers of the mice in each group were taken out and frozen, sliced ​​at a thickness of 6 μm, and stained with Oil Red O (Sigma, USA). is 100μm, the result is as image 3 shown.

[0035] See image 3 , image 3 It is a sliced ​​image of fat accumulation in the liver after Parabacteroides gordii in an embodiment of the present invention acts on obese mice fed a normal diet and a high-fat diet. It can be seen from the figure that compared with the normal diet rats, the fat accumulation of the high-fat diet rats increased a lot after 8 week...

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Abstract

The present invention relates to the use of anti-obesity properties of parabacteroides goldsteinii, in particular use of parabacteroides goldsteinii to treat fatty liver disease. The parabacteroides goldsteinii can reduce blood aspartate transaminase level, liver weight, hepatic lipid accumulation and hepatocyte hypertrophy. Therefore, parabacteroides goldsteinii can be utilized for the treatmentof fatty liver diseases and the preparation of related pharmaceutical compositions.

Description

technical field [0001] The invention relates to a use of Parabacteroides goldsteinii, in particular to an application of using Parabacteroides goldsteinii to inhibit or treat fatty liver disease. Background technique [0002] The so-called "fatty liver" means that the fat (mainly triglycerides) accumulated in the liver exceeds 10% of the total liver weight. Although this accumulation is a reversible condition, if not improved, it may lead to liver fibrosis and cirrhosis, or the risk of liver function not functioning normally. Fatty liver disease may be caused by a variety of factors, including excessive food or alcohol consumption, metabolic disorders (alipoproteinemia, glycogen storage disease, Vickers disease), malnutrition (malnutrition, severe weight loss, refeeding syndrome, gastric bypass surgery), drugs and toxins (amiodarone, highly active antiretroviral therapy, tamoxifen, methotrexate, glucocorticoids ( glucorcorticoids)] or other diseases (celiac disease, hepati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/16A23L33/135
CPCA23V2002/00A61K35/74A23L33/135A23V2200/30A61K35/741A61K2035/115A61P1/16A61K39/00
Inventor 柯云飞马奕安吴宗儒张志荣林诠盛廖建清王维章邱振尧陆嘉真欧大卫赖信志杨定一
Owner CHANG GUNG BIOTECH
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