Antibacterial material with adjustable antibacterial ability and preparation method thereof and application thereof

A technology of antibacterial materials and capabilities, applied in the field of antibacterial materials and their preparation, can solve the problems of inability to adjust antibacterial ability, long antibacterial time, poor antibacterial effect, etc., achieve stable effect, strong pertinence, and avoid the effect of external environment

Active Publication Date: 2019-03-08
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the use of natural clay for antibacterial treatment has the following problems: poor antibacterial effect and large dosage; long antibacterial time and low efficiency; antibacterial ability under the condition of pH9, which is easy to cause secondary damage to the body ; The antibacterial effect is poor, and the antibacterial ability cannot be adjusted according to actual needs

Method used

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  • Antibacterial material with adjustable antibacterial ability and preparation method thereof and application thereof
  • Antibacterial material with adjustable antibacterial ability and preparation method thereof and application thereof
  • Antibacterial material with adjustable antibacterial ability and preparation method thereof and application thereof

Examples

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Effect test

Embodiment approach

[0040] According to a preferred embodiment of the present invention, the chemical reduction method is to mix a chemical reducing agent with iron-containing natural clay,

[0041] The chemical reducing agent is a strong reducing agent, preferably selected from one or more of sodium dithionite, sodium hypophosphite, hydrazine hydrate or sodium bisulfite.

[0042] In a further preferred embodiment, the chemical reducing agent is one or more of sodium dithionite, sodium hypophosphite or sodium bisulfite.

[0043] In a further preferred embodiment, the chemical reducing agent is sodium dithionite.

[0044] According to a preferred embodiment of the present invention, the weight ratio of the iron-containing natural clay to the reducing agent is 1:(2-7), preferably 1:(3-6), more preferably 1:4.

[0045] According to a preferred embodiment of the present invention, the antibacterial regulator is a positive regulator that enhances the antibacterial ability of the reduced iron-containi...

Embodiment 1

[0126] (1) Take 1g of iron-containing nontronite (Sp_Clay_NAu-2; American Clay Society origin clay resource bank) and dissolve it in 100mL (sodium citrate-sodium bicarbonate buffer solution (the preparation method is to mix 1M sodium bicarbonate with 0.3M Sodium citrate is mixed according to the volume ratio of 8:1)), and ultrasonically stirred to make a suspension with a concentration of 10g / L, which is placed in a reaction container; the reaction container is first passed through nitrogen for 20min under the condition of a water bath at 100°C, and then Add 4g of sodium dithionite to it, continue to pass nitrogen gas for 5 minutes, seal the reactor, place it in an oven at 60°C for 24 hours, and obtain a reduced iron-containing nontronite. The reduced nontronite needs to be used in an anaerobic box. Wash three times with deionized water;

[0127] (2) Detect the concentration of ferrous iron in the reduced iron-containing nontronite, the steps are as follows:

[0128] (2.1) Ta...

Embodiment 2

[0134] The reduced iron-containing nontronite (calculated as ferrous iron), ascorbic acid and MES (pre-adjusted to pH 6) were mixed in a molar ratio of 3:2:2, and the three were shaken and mixed in an anaerobic operation box for 30 minutes. Freeze-drying is carried out under vacuum conditions to obtain antibacterial materials.

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Abstract

The invention discloses an antibacterial material with adjustable antibacterial ability and a preparation method thereof and application thereof. The antibacterial material with the adjustable antibacterial ability comprises reduced ferruginous clay with the antibacterial ability and an antibacterial regulator used for adjusting the antibacterial ability of the reduced ferruginous clay; the antibacterial regulator comprises a positive regulator and a negative regulator; and an antibacterial effect can be adjusted according to actual use demands under a condition of being mild to skins. The preparation method of the antibacterial material with the adjustable antibacterial ability, disclosed by the invention, has the advantages of simple operation, easily controlled condition and low requirements on equipment.

Description

technical field [0001] The invention belongs to the field of antibacterial drugs, and in particular relates to an antibacterial material with adjustable antibacterial ability, a preparation method and application thereof. Background technique [0002] Since antibiotics mainly act on specific components or structures in the cells of the body, they have certain side effects on the body. Moreover, with the widespread use of antibiotics, a large number of resistant strains and superbugs continue to emerge, and the research and development cycle of new antibiotics is extremely long and expensive, resulting in great disadvantages of antibiotics. In response to this situation, finding antibacterial drugs that can replace antibiotics has become a hot research field. [0003] In recent years, relevant scholars have found that natural clay can be used instead of antibiotics for antibacterial, and the existing clay minerals collected in nature can be directly applied to the affected a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61P31/04A61K31/375
CPCA61K31/375A61K33/26A61P31/04A61K2300/00
Inventor 王曦董海良夏庆银
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)
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