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Schefflera octophylla leaf extractive and extracting method thereof and application thereof in preparation of blood coagulation promoting and hemostasis drugs

An extraction method and a technique for Liriodendron chinensis leaves, which are applied in the field of medicine or/and health care products to achieve remarkable effects and remarkable hemostasis.

Inactive Publication Date: 2019-03-08
HUAQIAO UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic and foreign researches on the biological activity of Scherichia safflower mainly focus on the anti-inflammatory and analgesic activities, and there are no related reports on the procoagulant and hemostatic activities of Scherichia spp.

Method used

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  • Schefflera octophylla leaf extractive and extracting method thereof and application thereof in preparation of blood coagulation promoting and hemostasis drugs
  • Schefflera octophylla leaf extractive and extracting method thereof and application thereof in preparation of blood coagulation promoting and hemostasis drugs
  • Schefflera octophylla leaf extractive and extracting method thereof and application thereof in preparation of blood coagulation promoting and hemostasis drugs

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Embodiment 1

[0019] A kind of extracting method of Scherichia cheifera leaf extract, it comprises the steps:

[0020] 1) Extract 10 kg of dried Scherichia cheifera leaves with 45L of 70% ethanol at room temperature for 3 times, each time for 3 days, combine the filtrates, and concentrate under reduced pressure to obtain 5 kg of the total extract;

[0021] 2) The total extract was extracted with petroleum ether and ethyl acetate respectively (extracted three times, each time for one day), and the ethyl acetate part was eluted with a gradient of dichloromethane-methanol through silica gel column chromatography, with a volume ratio of 100 :0—1:1 (i.e. 100:0, 100:1, 50:1, 20:1, 10:1, 5:1, 1:1), six components were obtained by TLC thin layer chromatography detection and combination, According to the polarity of the obtained components, they are marked as F1 to F6 in order;

[0022] 3) Pass 80g of component F5 through the ODS open column, elute with methanol-water gradient, the volume ratio is ...

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Abstract

The invention discloses an extracting method of a schefflera octophylla leaf extractive. The method specifically comprises the following steps: 1) digesting schefflera octophylla leaves through ethylalcohol; performing pressure-reduced concentration to obtain a total extractive; 2) correspondingly extracting the total extractive through petroleum ether and ethyl acetate; processing the ethyl acetate by column chromatography on silica gel; performing gradient eluting through dichloromethane-methyl alcohol to obtain six components; and sequentially marking as F1 to F6 based on the polarity fromlow to high; and 3) processing the component F5 through an ODS open column; performing gradient eluting through methyl alcohol-water to obtain ten components; sequentially marking as components 1 to10 based on the polarity from low to high, wherein the component 4 is the schefflera octophylla leaf extractive. The identification result shows that the effective component of the schefflera octophylla leaf extractive is 3-oxo-sulfonic betulinic acid; various biochemical indexes of the schefflera octophylla leaf extractive to a rat with heparin sodium are tested, and the blood coagulation promoting and hemostasis effects are tested; the results show that the blood coagulation promoting and hemostasis effect to the rat are obvious.

Description

technical field [0001] The invention belongs to the field of medicine and / or health care products, and in particular relates to an extract of Scherichia safflower leaves and its extraction method, and its application in the research and development of preparation of blood-promoting and hemostatic drugs. Background technique [0002] Procoagulant and hemostatic drugs refer to drugs that can stop internal and external bleeding. Blood is an important substance in the human body. In the case of unexpected massive bleeding, if the bleeding is not stopped effectively in time, it may lead to coma, shock or even life-threatening. During the operation, the use of hemostatic drugs can also enhance the clarity of the doctor's field of vision, avoid important tissue damage, shorten operation time, reduce postoperative drainage, shorten hemostasis time and reduce the chance of infection. Therefore, the application of hemostatic drugs has important clinical significance. The number of p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61P7/04
CPCA61P7/04C07J63/008
Inventor 许瑞安康文艺刘绪强牛英颖
Owner HUAQIAO UNIVERSITY
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