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Separation chip and method for manufacturing the same

A separation chip and manufacturing method technology, applied in the direction of sterilization methods, methods of supporting/immobilizing microorganisms, biochemical equipment and methods, etc., which can solve the problem of partial pressure of membrane pore blockage, affecting the purity of target components, and rupture of filter membranes, etc. problems, to achieve high-throughput separation and extraction, reduce detection costs, and reduce workload

Active Publication Date: 2019-03-08
SHENZHEN HUIXIN LIFE TECH CO LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, in the actual operation process, some components in the biological sample are easy to be enriched on the filter membrane, and the components larger than the membrane pore size will block the membrane pores
Membrane pore blockage will prevent components smaller than the membrane pore size from effectively passing through the filter membrane, affecting the purity of the target component after separation
Membrane pore clogging can also cause excessive local pressure, and even cause the filter membrane to rupture

Method used

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  • Separation chip and method for manufacturing the same
  • Separation chip and method for manufacturing the same
  • Separation chip and method for manufacturing the same

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Embodiment Construction

[0052] The technical solutions of the present invention will be described below in combination with preferred implementation modes and examples of the present invention. It should be noted that when an element is described as being "connected" to another element, it can be directly connected to the other element or there may be intervening elements at the same time. When an element is described as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The names of elements or devices used in the description of the present invention are only for the purpose of describing specific embodiments, and are not intended to limit the present invention.

[0053] An embodiment of the present invention provides a separation chip, which is us...

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Abstract

A separation chip comprising: a sample cell; a first filter membrane; a second filter membrane; a first chamber, which communicates with the sample pool through the first filter membrane, the first chamber being provided with a first opening for communicating the first chamber with the outside; a second chamber which is connected to the sample pool by the second filter membrane. The second chamberis provided with a second opening for communicating the second chamber with the outside. The first chamber and the second chamber are respectively located on opposite sides of the sample pool.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a separation chip for separating target particles in a liquid sample and a manufacturing method of the separation chip. Background technique [0002] Liquid biopsy (liquid biopsy or fluid biopsy) is a sampling and analysis method that can comprehensively and real-time reflect the biological information of tumor cells or tissues. Liquid biopsy has the advantage of being non-invasive. By separating and analyzing specific research objects in blood or other body fluids (urine, saliva, pleural effusion, cerebrospinal fluid, etc.), dynamic observation of tumors can guide medical staff to screen for tumors , diagnosis, prognosis, selection of treatment options and monitoring of recurrence, etc. Specific research objects in liquid biopsy include circulating tumor DNA (circulating tumor DNA, ctDNA), circulating tumor cells (circulating tumor cell, CTC), microvesicles (also known as exosomes,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/12
CPCC12M23/34C12M29/04C12M41/44
Inventor 陈欲超
Owner SHENZHEN HUIXIN LIFE TECH CO LTD
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