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Functional food and medicine for preventing and treating alcoholic psychosis and making method of functional food and medicine

A technology for functional food and mental disorders, applied in the functions of food ingredients, food ingredients, food ingredients containing natural extracts, etc., can solve problems such as lack of good products and damage to the nervous system

Inactive Publication Date: 2019-04-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the products currently being developed for the prevention and treatment of alcoholism are liver protection products developed for alcohol-induced liver damage. For alcohol-induced nervous system damage, especially alcoholism mental disorders, there is a lack of good products

Method used

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  • Functional food and medicine for preventing and treating alcoholic psychosis and making method of functional food and medicine
  • Functional food and medicine for preventing and treating alcoholic psychosis and making method of functional food and medicine
  • Functional food and medicine for preventing and treating alcoholic psychosis and making method of functional food and medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Preparation of sulforaphane oral liquid provided by the present invention

[0021] Formula: sulforaphane 500mg, add corn oil 1000ml. Stir to dissolve. Add the right amount of sucrose. Add citric acid and sodium citrate to adjust the pH to 5.7. Stir evenly, filter and pack, and store at low temperature (4 degrees). Suggested dosage: 10-20ml / day for adults.

Embodiment 2

[0022] Embodiment 2 Oral liquid of the present invention significantly delays the sleep time of mice caused by ethanol

[0023] 10-12 weeks of mice, 25-30g intraperitoneal injection of sulforaphane 5mg / kg for 5 consecutive days, on the 6th day to detect the loss of righting reflex induced by acute alcohol administration: mice were injected intraperitoneally with 20% v at 4.0g / kg concentration / v alcohol solution, after the mouse righting reflex disappears, the mouse is placed in a V-shaped device, and the total time of the mouse righting reflex disappearing is recorded as the sleep time of the mouse. The results prove that sulforaphane can significantly reduce alcohol-induced sleep duration of mice. Control: 43.37±5.264 minutes; Sulforaphane: 31.00±5.091 minutes. N=10. The experimental results can be found in the attached figure 1 .

Embodiment 3

[0024] Example 3 The oral liquid of the present invention significantly inhibits the decrease in rectal temperature of mice caused by ethanol

[0025] Mice at 10-12 weeks were given intraperitoneal injection of sulforaphane 5 mg / kg at 25-30 g for 5 consecutive days, and the decrease in core body temperature induced by acute alcohol administration was detected on the 6th day. Use a rectal thermometer to detect the hourly basal body temperature, then inject the mice with 20% v / v alcohol solution at a concentration of 3.0g / kg intraperitoneally, and measure the core of the mice after 30 minutes, 60 minutes, 90 minutes and 120 minutes after the alcohol administration Body temperature, taking the average value of these four body temperatures, and calculating the absolute value of the drop in mouse body temperature, it was found that sulforaphane can significantly alleviate the drop in core body temperature induced by alcohol. Control: 2.269±0.1618 degrees Celsius; Sulforaphane: 1.64...

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Abstract

The invention discloses a technical scheme of application of a raphanin or a plant extract with the raphanin in preparing a functional food or medicine for preventing and treating alcoholic psychosis.Researches show that the raphanin is capable of enhancing the expression of catalase in a body by activating Nrf2 transcription activity, so that a powerful capability that ethanol is converted intoacetaldehyde is resulted in a brain, and the inhibition effect of the ethanol upon the brain can be alleviated. Therefore, the raphanin can be adopted to prepare medicines and functional foods for preventing or treating alcoholism. The raphanin can be a chemical monomer, or the plant extract with the raphanin can be also used.

Description

technical field [0001] The invention belongs to the technical field of functional foods and medicines, and relates to functional foods and medicines for preventing and treating alcoholic mental disorders and a preparation method thereof. Background technique [0002] my country is a big drinking country. Alcoholism, commonly known as drunkenness, refers to the abnormal state of body function that occurs after a patient drinks a large amount of alcohol (ethanol), and the damage to the nervous system and liver is the most serious. Medically, it is divided into acute poisoning and chronic poisoning. The former brings harm to the patient in a short period of time, and can even cause respiratory and heartbeat suppression and cause death. The latter brings cumulative harm to patients, such as alcohol dependence, mental disorders, alcoholic cirrhosis and induction of cancer. Mild patients may experience mental abnormalities, such as talkativeness, irritability, flushed or pale co...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K31/26A61K36/31A61K9/08A61K9/48A61P39/02A61P25/18
CPCA23V2002/00A61K9/0095A61K9/48A61K31/26A61K36/31A61K47/26A61K2236/35A23L33/00A23V2250/21A23V2200/334
Inventor 陈建国吴鹏飞王芳王文罗涵韩倩倩
Owner HUAZHONG UNIV OF SCI & TECH
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