Long afterglow nanomaterial with internal irradiation and photodynamic dual therapy and dual-mode imaging and preparation method thereof

Abstract

The invention relates to a long persistent nano material with internal irradiation and photodynamics dual therapies and bimodal imaging, and a preparation method thereof. The material is prepared by the following steps: first, preparation of ZGO-ZnPc(COOH)4: 1, I, preparing a NaOH solution; II, allowing ZGO powder to react with a NaOH solution; III, performing centrifuging, drying the precipitatein an oven, and collecting ZGO-OH powder for later use; and VI, performing re-dissolving to obtain a re-dissolved fluid; 2, I, performing activation to obtain an activated ZnPc(COOH)4 solution; 3, I,adding the re-dissolved fluid to the activated ZnPc(COOH)4 solution; II, adding methoxy PEG 5000 and hydroxyphenylpropionic acid-N-hydroxysuccinimide ester, and performing stirring in dark place; and4, performing centrifuging, then adding a DMF for re-dissolving, then performing centrifuging, repeating the above re-dissolving and centrifuging, performing drying, and collecting ZGO-ZnPc(COOH)4 powder into an LEP tube in a dark place for later use; and second, 1, preparing an idogen coating tube; and 2, adding the prepared ZGO-ZnPc(COOH)4 powder together with corresponding mGi / uGi 131I into theidogen coating tube, and performing oscillating reaction to obtain 131I-ZGO-ZnPc(COOH)4. The material has internal irradiation and photodynamics dual therapies, has SPECT and IVIS bimodal imaging effects, and has the advantages of good chemical stability and biodistributivity and high specific activity.

Description

technical field [0001] The invention relates to a nanometer material with imaging function, in particular to a long afterglow nanometer material with dual-mode imaging effects of internal irradiation and photodynamic therapy and a preparation method thereof. Background technique [0002] Photodynamic therapy (Photodynamics Therapy, PDT) is a promising new method for the treatment of a variety of tumors. It excites photosensitizers to generate singlet oxygen and other reactive oxygen species by light of specific wavelengths, resulting in lipid hyperactivity in organisms. Oxidation, photooxidative damage of DNA guanine and serial damage to cell membrane, cytoskeleton and other parts eventually lead to cell death. Limited by the penetration depth of the excitation light source and thermal damage side effects. Long Persistent Luminescence (LPL) materials are also known as light-storing luminescent materials, commonly known as long-lasting luminescence powders. Its luminescence...

AI Technical Summary

Problems solved by technology

[0005] However, there is currently a lack of multimodal imaging materials with good chemical stability, biodistribution, and high specific activity.

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