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A kind of myocardial repair hydrogel material and preparation method thereof

A technology of gel material and water repair, applied in the field of biomimetic materials, can solve problems such as restricting the development of myocardial repair materials, and achieve the effects of accelerating vascularization, good electrical conductivity, and good biological activity

Active Publication Date: 2022-01-14
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current myocardial repair materials only meet the first condition, which limits the development of myocardial repair materials

Method used

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  • A kind of myocardial repair hydrogel material and preparation method thereof
  • A kind of myocardial repair hydrogel material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A myocardial repair hydrogel material, comprising the following components by weight: 10 parts of aminated sodium hyaluronate, 40 parts of oxidized hydroxypropyl methylcellulose, 2 parts of pyridine, 0.05 parts of human bone marrow mesenchymal stem cells, The concentration of vascular endothelial growth factor is one part per 200,000. Wherein, the molecular weight of sodium hyaluronate used in the preparation process is 2×10 6 kDa, the viscosity of hydroxypropyl methylcellulose is 50mpa·s, and the volume ratio of solution A to solution B is 1:4.

[0033] The preparation method of the myocardial repair hydrogel material of the present embodiment is as follows:

[0034] (1) Preparation of Aminated Sodium Hyaluronate

[0035] Weigh sodium hyaluronate (HA), add 100ml of distilled water, stir with a magnetic stirrer until dissolved, prepare a 3% HA solution, add an ammoniating agent to dissolve in the HA solution, and then add 1% of HA mass 4-dimethyl Aminopyridine (DAMP)...

Embodiment 2

[0044] A myocardial repair hydrogel material, comprising the following components in parts by weight: 20 parts of aminated sodium hyaluronate, 20 parts of oxidized hydroxypropyl methylcellulose, 1 part of pyridine, 0.1 part of human bone marrow mesenchymal stem cells, Parts per million of vascular endothelial growth factor. Wherein, the molecular weight of sodium hyaluronate in the preparation process is 8×10 6 kDa, the viscosity of hydroxypropyl methylcellulose is 15mpa s; the volume ratio of solution A to solution B is 1:1.

[0045] The preparation method of the myocardial repair hydrogel material in this example is the same as that in Example 1.

Embodiment 3

[0047] A myocardial repair hydrogel material, comprising the following components in parts by weight: 5 parts of aminated sodium hyaluronate, 60 parts of oxidized hydroxypropyl methylcellulose, 5 parts of pyridine, 0.05 parts of human bone marrow mesenchymal stem cells, One part per hundred thousandth of vascular endothelial growth factor. Wherein, the molecular weight of sodium hyaluronate in the preparation process is 2×10 6 kDa, the viscosity of hydroxypropyl methylcellulose is 50mpa s; the volume ratio of solution A to solution B is 1:12.

[0048] The preparation method of the myocardial repair hydrogel material in this example is the same as that in Example 1.

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Abstract

The invention relates to a myocardial repair hydrogel material and a preparation method thereof, belonging to the technical field of bionic materials. The myocardial repair hydrogel material of the present invention comprises the following components in parts by weight: 5-20 parts of aminated sodium hyaluronate, 20-60 parts of oxidized hydroxypropyl methylcellulose, 1-5 parts of pyridine, human bone marrow 0.05-0.1 part of mesenchymal stem cells, 1 part per 100,000 to 1 part per million of vascular endothelial growth factor. The myocardial repair hydrogel material of the present invention is beneficial to the aggregation of vascular endothelial cells and platelets, accelerates the vascularization of the reconstruction site, and is beneficial to the repair of the myocardial infarction site; it can conduct the electrical impulse generated by the normal myocardium, and can contract synchronously with the heart , to prevent arrhythmia caused by asynchronous movement after transplantation; it is beneficial to the assimilation of the host after material implantation.

Description

technical field [0001] The invention relates to a myocardial repair hydrogel material and a preparation method thereof, belonging to the technical field of bionic materials. Background technique [0002] Myocardial infarction refers to myocardial necrosis caused by acute and persistent ischemia and hypoxia, and is a disease that threatens human life. At present, there are at least 2 million myocardial infarction patients in China, and the number of new cases is increasing at least 500,000 each year. [0003] When a heart vessel is infarcted, a certain range of cardiomyocytes is lost, and fibrous tissue is formed to affect heart function. This damage to the heart is irreversible because adult cardiomyocytes cannot regenerate. The effective way to reverse this damage is to replenish the lost cardiomyocytes by directly injecting cardiomyocytes into the myocardial infarction area, but the survival rate of cardiomyocytes supplemented by this method is not high, and immune rejec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/54A61L27/22A61L27/00A61L27/38A61L27/20C08J3/075C08L1/28C08L5/08C08B37/08
CPCA61L27/00A61L27/20A61L27/227A61L27/3834A61L27/50A61L27/52A61L27/54C08B37/0072C08J3/075A61L2430/20A61L2300/252A61L2300/414A61L2300/412A61L2400/06C08J2301/28C08J2405/08C08L89/00C08L1/28C08L5/08
Inventor 蓝咏郭瑞刘玉陈泰瀛朱麒宇
Owner BEOGENE BIOTECH GUANGZHOU
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