Application of posaconazole to preparation of bactericide for controlling plant pathogenic bacteria

A technology for plant pathogenic bacteria and posaconazole, which is applied in the application field of fungicides, can solve problems such as harm, drug residues, and kill non-target organisms, and achieves broad market application prospects, good inhibitory activity, and the effect of good inhibitory activity.

Pending Publication Date: 2019-04-26
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term use of large quantities of chemical pesticides not only leads to resistance problems, but also causes pesticide residues, kills non-target organisms, pollutes the ecological environment, and eventually causes harm to the human body through bioaccumulation

Method used

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  • Application of posaconazole to preparation of bactericide for controlling plant pathogenic bacteria
  • Application of posaconazole to preparation of bactericide for controlling plant pathogenic bacteria
  • Application of posaconazole to preparation of bactericide for controlling plant pathogenic bacteria

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Experimental program
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Effect test

Embodiment 1

[0030] In the InterBioScreen database (https: / / www.ibscreen.com / ), the present invention screened and synthesized the small molecule compound posacan based on the three-dimensional structure design of Fusarium graminearum CYP51B protein (sterol demethylation inhibitor target protein) azole.

[0031] Chemical name: 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-yl Methyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypent-3-yl]-1 , 2,4-triazol-3-one;

[0032] English:

[0033] 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one, molecular formula: C 37 h 42 f 2 N 8 o 4 , molecular weight: 700.78, the structural formula is as follows:

[0034]

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PUM

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Abstract

The invention discloses application of posaconazole to preparation of a bactericide for controlling plant pathogenic bacteria. Determination of indoor drug sensitivity proves that the posaconazole hasgood activity in inhibiting main diseases of important food crops, including wheat scab-causing fusarium graminearum, rice blast-causing magnaporthe oryzae, sheath blight-causing rhizoctonia cerealisand corn leaf spot-causing maize curvularia, has good activity in inhibiting botrytis cinerea, physalospora piricola, valsa ceratosperma and alternaria tenuissima, and has relatively good activity ininhibiting soil-borne diseases such as fusarium oxysporum, which are extremely difficult to control in agricultural production, and the bacteriostatic activity of the posaconazole is even superior tothose of the conventional bactericides carbendazim and tebuconazole. The invention proposes screening of the green small molecular compound posaconazole from the three-dimensional structure of targetprotein for the first time, and the posaconazole is applied to control of important plant diseases in the agricultural production and has a broad market application prospect.

Description

technical field [0001] The invention belongs to the technical field of plant protection, and in particular relates to the application of posaconazole in the preparation of fungicides for preventing and treating plant pathogenic bacteria. Background technique [0002] The Food and Agriculture Organization of the United Nations (FAO) estimates that the loss of crop production in the world is about 40% (440-550 billion yuan) due to damage from diseases, insect pests and weeds, and the impact on trees is even more difficult to estimate. The losses recovered through the work of scientists and various technology extension personnel engaged in pest research all over the world reached 300-400 billion yuan. For a long time, chemical control has been the main means of controlling plant diseases. The long-term use of large quantities of chemical pesticides not only leads to resistance problems, but also causes pesticide residues, kills non-target organisms, pollutes the ecological env...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/653A01P3/00A01P1/00
CPCA01N43/653
Inventor 黄金光孙慧琳赵彦翔孙晓梅张淑颖
Owner QINGDAO AGRI UNIV
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