High-molecular anti-tumor medicine for bonding vascular disrupting agent and immunomodulatory agent and preparation method thereof

Abstract

The invention discloses a high-molecular anti-tumor medicine for bonding a vascular disrupting agent and an immunomodulatory agent and a preparation method thereof. According to the high-molecular anti-tumor medicine, a polyethylene glycol block and a polylactide block serve as main chains, and the vascular disrupting agent and immunomodulatory agent pharmaceutical molecules are grafted and bondedat the same time on the main chins through chemical reactions such as a sulfydryl-alkene light click reaction, an esterification reaction and a nitrine-alkyne cyclic addition reaction. Due to the synergistic effect of the tumor vascular occlusion therapy and the immune therapy, the high-molecular anti-tumor medicine improves the anti-cancer activity under the condition that the dosage of the medicine is reduced, and the defects that a traditional chemotherapeutic has difficulty in infiltrating in tumor cells and has drug resistance are avoided; meanwhile, the immune therapy is used for activating the immune system of a patient to kill the tumor cells for a long time, and clinical tumor metastasis and relapse are effectively prevented. In addition, a synthetic method of the anti-tumor polymer bonding medicine has the advantages of being simple, effective, mild in reaction condition and the like.

Description

technical field [0001] The invention relates to a polymer anti-tumor drug, in particular to an anti-tumor polymer-bonded drug simultaneously bonded with a blood vessel blocking agent and an immunomodulator, and a preparation method thereof; belonging to the field of biomedical polymer materials. Background technique [0002] As a global public health problem, tumors have greatly endangered human health, and have become the leading cause of human death in the new century. At present, cancer treatment mainly includes chemotherapy, surgical treatment, radiotherapy and other main methods. Although traditional chemotherapy has been improved for a long time, there are still problems such as the difficulty of anticancer drugs penetrating into the tumor and long-term use to produce drug resistance, which makes the treatment effect not good. Satisfactory, but both radiation therapy and surgical treatment have defects such as high toxicity and side effects, and easy to cause tumor cel...

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems that traditional chemotherapy is prone to drug resistance, chemotherapy drugs cannot penetrate into the tumor, and tumors are pr

Images