A processing method for microfluidic chip with special-shaped cross-section based on fdm three-dimensional printing
A special-shaped cross-section and processing method technology, which is applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the limitation of molding accuracy, the gas permeability, light transmittance and biocompatibility of photosensitive resin materials Insufficient and other problems, to achieve the effect of low processing cost, wide application range and good biocompatibility
Active Publication Date: 2021-02-02
NANJING NORMAL UNIVERSITY +1
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Problems solved by technology
However, at present, the application of 3D printing technology in microfluidic chip processing mainly focuses on the construction of complex spatial flow channel structures, and there are still few reports on the 3D printing of flow channels with special-shaped cross-sections.
Although Lee et al. (Lab Chip, 2016, 16:668-678) have successfully printed a trapezoidal cross-section spiral channel by controlling the light source to expose and cure the photosensitive resin layer by layer, the molding accuracy of the micro-stereolithography technology used is limited. The application of this method in the machining of small-sized special-shaped cross-section runners
In addition, compared with the commonly used PDMS, photosensitive resin materials have obvious deficiencies in gas permeability, light transmission and biocompatibility.
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Embodiment 1
[0049] This embodiment relates to a processing method of a microfluidic chip based on FDM three-dimensional printing, specifically microfluidic processing with square, triangular and semi-elliptical cross-sections. The detailed processing process and results are as follows:
[0050] The special-shaped section of the present application can be designed as a square, semi-elliptical or isosceles triangle as the flow channel section, and the height and base length of all graphics are set to 200 microns. According to the designed cross-sectional shape of the flow channel, a picosecond laser is used to laser cut and process special-shaped micro-holes at the center of a 304 stainless steel circular sheet with a thickness of 100 microns and a diameter of 4 mm. Next, the tip of a standard 303 stainless steel nozzle is turned away to expose a circular platform with a diameter of 4 mm. Put the 304 stainless steel wafer and the 303 stainless steel nozzle into acetone and ultrasonically cl...
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Abstract
The invention provides a processing method of a special-shaped cross-section micro-channel chip based on FDM three-dimensional printing, comprising the following steps: step 1: processing an FDM nozzle with a special-shaped micro-hole; step 2: printing out a special-shaped cross-section micro-channel ABS positive Mold; Step 3: Make the PDMS base; Step 4: Transfer the ABS male mold to the top of the PDMS base, pour the PDMS solution and sequentially solidify and slice to obtain a PDMS block; Step 5: At the two ends of the ABS male mold on the PDMS block Process the vertical through hole; step 6: immerse the PDMS block in the ABS solution to dissolve the ABS male mold; step 7: inject the PDMS solution into one side of the vertical through hole, and form a micro-channel chip with a special-shaped cross-section after curing and sealing.
Description
technical field [0001] The invention relates to the field of microfluidic chip processing, in particular to a processing method for microfluidic chips with special-shaped cross-sections based on FDM three-dimensional printing. Background technique [0002] Inertial microfluidics skillfully utilizes the inertial effect of micro-scale fluids to achieve precise control of the particle motion state and equilibrium position. It has the obvious advantages of simple flow channel structure, no need for external fields and high processing throughput. It is a micro-nano An important enabling technology for the realization of biological particle focusing, alignment and sorting functions. However, limited by the vertical exposure process of classical soft lithography technology, the current research on inertial microfluidics technology is still mainly focused on conventional rectangular cross-section microfluidics. [0003] The research results of the mechanism of inertial manipulation...
Claims
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IPC IPC(8): B01L3/00
Inventor 唐文来李宗安朱莉娅施建平杨继全
Owner NANJING NORMAL UNIVERSITY