Plant hollow capsule and preparation method thereof

A plant hollow capsule and gel technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, can solve the problems of inconsistency in friability and disintegration time, and avoid drying water loss and absorption. Moisture, low water content, avoid shrinkage or swelling effect

Active Publication Date: 2019-06-07
CHONGQING HENGSHENG MEDICINAL CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a method for preparing vegetable-based hollow capsules by modifying and preparing hypromellose, and then collating related ingredients to improve the tightness of the hollow capsules. Performance, and solve the problem of inconsistent friability and disintegration time limit

Method used

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  • Plant hollow capsule and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0036] (1) Add 1 kg of microcrystalline cellulose to 100 kg of hypromellose and mix well to obtain modified hypromellose.

[0037] (2) Add 25kg of modified hypromellose to 57.5kg of purified water to disperse. The temperature of the purified water is 85°C when adding, and keep it under constant stirring for 30 minutes to obtain a cellulose solution.

[0038] (3) Take 237.5 g of gellan gum and add it to 63.75 kg of purified water to stir and swell. The temperature of the purified water is 17°C when adding, then heat to 90°C and keep it for 45 minutes to obtain gellan gum swelling liquid.

[0039] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 3°C higher than that of the cellulose solution, stir for 8 minutes, and mix evenly; cool to 60°C to obtain a cellulose gel solution.

[0040] (5) Add 125g of potassium citrate to 3.75kg of purified water and stir to dissolve. The temperature of the purified water is 50°C when adding, then add to the cellu...

Embodiment 2

[0045] (1) Add 5kgkg of microcrystalline cellulose to 100kg of hypromellose and mix well to obtain modified hypromellose.

[0046] (2) Add 100 kg of modified hypromellose to 245 kg of purified water to disperse. The temperature of the purified water is 87° C. when adding, keep stirring for 40 minutes to obtain a cellulose solution.

[0047] (3) Add 900 g of gellan gum to 235 kg of purified water and stir to swell. The temperature of the purified water is 17°C when adding, and then heated to 90°C and kept for 50 minutes to obtain gellan gum swelling liquid.

[0048] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 3°C higher than the temperature of the cellulose solution, and pour the cellulose solution and the gel swelling solution into the cellulose solution at the same time at a speed of 0.5kg / s. Mix in the kettle and start stirring when pouring, and continue stirring for 9 minutes after pouring, mix well, and then cool to 63°C to obtain a ...

Embodiment 3

[0054] (1) Add 8 kg of microcrystalline cellulose to 100 kg of hypromellose and mix well to obtain modified hypromellose.

[0055] (2) Add 100 kg of modified hypromellose to 250 kg of purified water to disperse. The temperature of the purified water is 90° C. when adding, keep stirring for 45 minutes to obtain a cellulose solution.

[0056] (3) Add 950 g of gellan gum to 240 kg of purified water and stir to swell. The temperature of the purified water is 20°C when adding, and then heated to 95°C and kept for 60 minutes to obtain gellan gum swelling liquid.

[0057] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 4°C higher than the temperature of the cellulose solution, and pour the cellulose solution and the gel swelling solution into the cellulose solution at the same time at a speed of 1.0kg / s. Mix in the kettle and start stirring when pouring, and continue stirring for 10 minutes after pouring, mix well, and then cool to 65°C to obtain a...

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Abstract

The invention provides a plant hollow capsule and a preparation method thereof, and belongs to the technical field of hollow capsule production. The plant hollow capsule is prepared from modified hydroxypropyl methylcellulose, gel, coagulant aid, plasticizer, surfactant and the balance of water, wherein the modified hydroxypropyl methylcellulose is prepared by adding a proper amount of microcrystalline cellulose into hydroxypropyl methylcellulose and performing uniform mixing. The plant hollow capsule has the beneficial effects that the capsule as certain moisturizing property besides the molding performance of a hydroxypropyl methylcellulose gel solution can be kept, moisture loss due to dryness and moisture absorption can be avoided in the storing process, shrinkage or expansion of a capsule shell can be avoided, occurrence of powder leakage can be effectively avoided, and the disintegrating speed of a capsule can be accelerated; the ductility and plasticization of the capsule can beimproved by properly adding the plasticizer, uniform wall thickness of the capsule can be guaranteed by combining with the gel; the disintegrating speed can be accelerated by properly adding the surfactant with the microcrystalline cellulose; and the friability can be effectively improved by properly adding the gel and the coagulant aid with the plasticizer.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant hollow capsule prepared from hypromellose as a raw material. Background technique [0002] In the century-old history of capsules, gelatin has always maintained its position as the mainstream capsule material due to its wide range of sources, stable physical and chemical properties, and excellent processing performance. With the increase of people's preference for capsules, hollow capsules are more widely used in the fields of food, medicine and health care products. [0003] Although gelatin capsules have been widely used, there are some insurmountable problems in gelatin capsules. For example, the main component of gelatin hollow capsules is protein, which is easy to breed and reproduce bacteria and microorganisms. Preservatives and antibacterial agents need to be added during the production process, and ethylene oxide must be used to sterilize the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38
Inventor 李全忠吴易果华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
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