Tuberculosis compositions and methods of treating or preventing tuberculosis

Abstract

The present disclosure provides fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, vectors comprising nucleic acid molecules, compositionscomprising the same, and methods of eliciting an immune response against tuberculosis.

Description

technical field [0001] The present disclosure relates in part to fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the fusion proteins, vectors comprising the nucleic acid molecules, compositions comprising them and methods of eliciting an immune response against tuberculosis. Background technique [0002] Tuberculosis (TB) is a global health problem resulting in 8 million new cases and 2 million deaths each year. The emergence of multidrug-resistant and fully drug-resistant TB strains will only exacerbate the problem. The life cycle of Mtb has 3 phases. In the acute phase after initial infection, bacteria replicate and express virulence factors in the host, leading to an immune response in the host. As the immune response begins to control the infection, Mtb enters a latent, asymptomatic state in which the bacteria become non-replicating and become encapsulated in granulomas. The bacteria can exist in this latent state ...

AI Technical Summary

Problems solved by technology

[0004] Although vaccines are often effective in immunizing individuals prophylactically or therapeutically against pathogenic infection or human disease, there remains a need for improved vaccines

Images