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Chitosan/polysulphobetaine ionic and covalent double-network hydrogel and production method thereof

A sulfobetaine, polysulfonic acid group technology, applied in chemical instruments and methods, alkali metal compounds, other chemical processes, etc., can solve problems such as poor stability and loose chitosan network, and achieve balanced water absorption performance, The effect of balanced water retention performance and stable network structure

Inactive Publication Date: 2019-07-05
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] In order to solve the obvious contradictions in the existing double network hydrogels in terms of good mechanical properties, good antifouling and antibacterial properties, and biocompatibility, and most chitosan double network hydrogels Chitosan network loose, poor stability and other problems, the invention provides a chitosan / polysulfobetaine ion-donating double-network hydrogel and its preparation method

Method used

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  • Chitosan/polysulphobetaine ionic and covalent double-network hydrogel and production method thereof
  • Chitosan/polysulphobetaine ionic and covalent double-network hydrogel and production method thereof
  • Chitosan/polysulphobetaine ionic and covalent double-network hydrogel and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A kind of preparation method of chitosan / polysulfobetaine ion supply double network hydrogel, described preparation method comprises the following preparation steps:

[0048] 1) Dissolve 2.8g sulfobetaine, 15mg initiator and 3mg cross-linking agent in 5mL water, stir for 10min, add 0.5g chitosan and ultrasonically shake for 30min to dissolve, prepare chitosan, sulfobetaine, initiator Mixed solution of agent and crosslinking agent;

[0049] 2) The mixed solution is placed in a mold, and the mold is composed of two pieces of glass sheets indirectly provided with a silicon rubber sheet with a thickness of 2mm. The mixed solution is placed in the mold and then sealed. The reaction was irradiated with ultraviolet light for 6 hours, and a pregel was obtained after the reaction;

[0050] 3) The pregel was immersed in a saturated trisodium citrate solution for 30 minutes to obtain the chitosan / polysulfobetaine ion-donating double network hydrogel.

[0051] Among them, sulfobe...

Embodiment 2

[0054] The difference between this example and Example 1 is that the chitosan added in step 1) is respectively 0.1 g, 0.2 g, 0.3 g, 0.4 g and 0.6 g; the remaining parts are exactly the same as in Example 1.

[0055] The tensile stress-strain curve of the chitosan / polysulfonic acid betaine ion-supplied double-network hydrogel prepared by the present embodiment is as follows: figure 1 As shown in the A curve, B curve, C curve, D curve and F curve, the tensile strength is 0.34MPa, 1.01MPa, 1.61MPa, 1.63MPa and 1.14MPa, and the elongation at break is 782%, 727%, 681%, 531%, and 292%.

Embodiment 3

[0057] A kind of preparation method of chitosan / polysulfobetaine ion supply double network hydrogel, described preparation method comprises the following preparation steps:

[0058] 1) Dissolve 0.7g sulfobetaine, 3.8mg initiator and 0.8mg cross-linking agent in 5mL water, stir for 10min, add 0.2g chitosan and ultrasonically shake for 30min to dissolve, and prepare chitosan and sulfobetaine , a mixed solution of an initiator and a crosslinking agent;

[0059] 2) The mixed solution is placed in a mold, and the mold is composed of two pieces of glass sheets indirectly provided with a silicon rubber sheet with a thickness of 2mm. The mixed solution is placed in the mold and then sealed. The reaction was irradiated with ultraviolet light for 6 hours, and a pregel was obtained after the reaction;

[0060] 3) The pregel was immersed in a saturated trisodium citrate solution for 30 minutes to obtain the chitosan / polysulfobetaine ion-donating double network hydrogel.

[0061] Among the...

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Abstract

The invention relates to the technical field of polymer hydrogel, in particular to chitosan / polysulphobetaine ionic and covalent double-network hydrogel and a production method thereof. The chitosan / polysulphobetaine ionic and covalent double-network hydrogel is of a double-network structure, and is formed through interpenetration of a first network and a second network, wherein the first networkis a physical cross-linking network formed through coordination of chitosan and multivalent anions, the second network is a chemical cross-linking network formed by polysulphobetaine, and the first network interpenetrates the second network. The produced double-network hydrogel has excellent obdurability and elasticity, further has good antibacterial performance, nonspecific protein adsorption resistance performance and cell adhesion resistance performance, and thus has wide application prospects in the field of biomedical application; and a production method is concise, efficient and environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of polymer hydrogels, in particular to a chitosan / polysulfobetaine ion-donating double-network hydrogel and a preparation method thereof. Background technique [0002] Hydrogels composed of polymer networks and water are similar in composition to biological tissues, thus, hydrogels have received high attention as synthetic equivalents in biological systems for various applications. However, the practical application of traditional hydrogels is limited by their poor mechanical properties (Advanced Materials, 2016, 28(24):4884-4890.). To date, many approaches have been developed to fabricate hydrogels with excellent mechanical properties, most notably double-network hydrogels (DN gels) consisting of a brittle first network and a flexible second network. [0003] As a natural polymer, chitosan (CS) has excellent biological functionality, compatibility, blood compatibility, safety, and microbial degradability, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L33/14C08F220/36C08F222/38C08F2/48B01J20/24B01J20/26B01J20/28B01J20/30
CPCB01J20/24B01J20/261B01J20/28047C08F2/48C08F220/36C08J3/075C08J3/243C08J2333/14C08J2405/08C08F222/385
Inventor 张静沈彪冯杰
Owner ZHEJIANG UNIV OF TECH
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