Treatment of obesity and eating disorders

An obesity, appetite technique, applied in the field of treatment of obesity and eating disorders, capable of addressing issues such as the possible role of metabolic effects not ruled out

Active Publication Date: 2019-07-30
ST VINCENTS HOSPITAL SYDNEY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, more factors are suspected to be involved, and it is worth noting that the above studies do not excl...

Method used

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  • Treatment of obesity and eating disorders
  • Treatment of obesity and eating disorders
  • Treatment of obesity and eating disorders

Examples

Experimental program
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Effect test

example 1

[0150] Example 1 Effect of MIC-1 on weight loss in obese mice

[0151] The study was performed using groups of ten (10) male 22-week-old C57BL6 mice fed chow (CHOW) or diet-induced obesity (DIO) from a 12-week high-fat diet (HFD). Via an osmotic micropump (ag model2002; Durect Corporation, Cupertino, San Francisco, USA), according to previously described methods 21 , mice were infused with vehicle (CHOWc or DIOc) or recombinant murine MIC-1 (0.5 μg / gBW / day; CHOWm or DIOm). found that MIC-1 induces sustained weight loss accompanied by a reduction in food intake ( Figure 1A and B), which in HFD (14%) mice were chow-fed mice (7%, Figure 1A ); despite having much lower steady-state serum MIC-1 levels (6.3+ / -0.8 ng / ml vs 10.7+ / -1.3 ng / ml, respectively; p Figure 1C and D). Furthermore, inguinal adipose tissue from DIOm mice showed much lower normalized qPCR expression of the macrophage marker F4 / 80 (10.3+ / -1.9vs73.2+ / -10.5; p72 .

[0152] Therefore, the data obtained in this...

example 2

[0153] Example 2 Increased weight loss in mice infused with MIC-1 + leptin

[0154] Use vehicle, recombinant mouse MIC-1 (0.5 μg / g body weight / 24 hours), leptin (0.5 μg / g body weight / 24 hours), or MIC-1+leptin (0.5 μg / g body weight MIC-1+ 0.5 μg / g body weight leptin / 24 hours) continuous infusion (using a standard osmotic minipump) for six (6) days was fed to 11-week-old C57BL6 mice for the study. Leptin was recombinant mouse leptin derived from Creative Biomart (Shirley, New York, USA).

[0155] The results are shown in figure 2 middle. After 6 days, mice treated with MIC-1 + leptin had significantly lower body weight than that observed with MIC-1 or leptin alone, suggesting a substantial complementary interaction between the two adipokines. Furthermore, since the DIO mice used in Example 1 were leptin resistant, the results obtained here suggest that MIC-1 can also alleviate leptin resistance. This is also consistent with applicants' previous work showing that MIC-1 is ef...

example 3

[0157] Example 3 Significant increase in body weight loss in HFD mice infused with MIC-1+leptin

[0158] Vehicle, murine leptin (0.5 μg / g / day) and recombinant murine MIC-1 (0.5 μg / g / day) were infused as a binary combination into normal chow-fed male mice and fed a high-fat diet for 24 weeks Obesity (diet-induced obesity (DIO) mice) and leptin-resistant male mice were subsequently induced. The results are shown in Figure 3A and 3B middle. The greatest weight loss was found when mice were infused with a combination of MIC-1 and leptin. The magnitude of weight loss observed with the combination of MIC-1 and leptin was particularly pronounced for HFD mice.

[0159] The results confirmed that HFD mice were more sensitive to MIC-1-induced weight loss than chow-fed mice. In particular, it was observed in this study that the HFD mice lost proportionally more weight and continued to lose weight, whereas the weight loss of the chow-fed mice plateaued for about 11 days. Furthermor...

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Abstract

Methods for controlling body weight and/or appetite in a subject are disclosed. In some embodiments, the methods involve administering to an overweight or obese subject an effective amount of a firstagent comprising MIC-1, a MIC- 1 agonist and/or a MIC-1-inducing agent, and a second agent comprising leptin and/or a leptin agonist, for the purpose of achieving weight loss. In other embodiments, the methods involve administering to an anorexic or cachectic subject an effective amount of a MIC-1-inhibiting agent and a leptin-inhibiting agent, for the purpose of increasing body weight and/or appetite in a subject.

Description

technical field [0001] The present disclosure relates to methods for controlling body weight and / or appetite in a subject. In a particular application, the method comprises administering to an overweight or obese subject an effective amount of a first agent comprising MIC-1 and / or a MIC-1 agonist and a second agent comprising leptin and / or a leptin agonist. Medicaments for achieving weight loss. [0002] priority document [0003] This application claims priority to Australian Provisional Patent Application No. 2016905018, entitled "Treatment of obesity and eating disorders", filed 6 December 2016, the contents of which are hereby incorporated by reference in their entirety. [0004] incorporated by reference [0005] The following applications or publications are cited in this application and the contents of which are hereby incorporated by reference in their entirety: [0006] Amirah E-E A et al., Expert Opin Drug Deliv 12(12):1923-1941(2015); [0007] International Pat...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K38/22A61K39/395A61P3/04A61P1/14
CPCA61P3/04A61P1/14A61K38/18A61K38/2264A61K2300/00C07K16/22C07K16/26
Inventor 萨穆埃尔·诺伯特·柏尔特
Owner ST VINCENTS HOSPITAL SYDNEY
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