A chitosan/ha-based personalized cranial, maxillofacial, and vertebral repair material and preparation method thereof

A technology for repairing materials and chitosan, applied in the field of biomedicine, can solve problems such as insufficient mechanical properties, and achieve the effects of bone tissue regeneration, strong osteogenic ability, and improved mechanical properties.

Active Publication Date: 2021-12-07
福建吉特瑞生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a chitosan / HA-based personalized cranial, maxillofacial, and vertebral bone repair material and its preparation method to meet the strength requirements of bone defect repair at load-bearing parts in view of the insufficient mechanical properties of the current chitosan-based materials.

Method used

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  • A chitosan/ha-based personalized cranial, maxillofacial, and vertebral repair material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0028] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0029] (2) Preparation of gel: Lay a layer of filter paper soaked in coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue to precipitate for 5 hours to obtain white gel;

[0030] (3) Preparation of substr...

Embodiment 2

[0039] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0040] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0041](2) Preparation of gel: Lay a layer of filter paper soaked in coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue to precipitate for 6 hours to obtain white gel;

[0042] (3) Preparation of substra...

Embodiment 3

[0050] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0051] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0052] (2) Preparation of the gel: Lay a layer of filter paper soaked in the coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue the precipitation for 5.5 hours. A white gel was obtained;

[0053] (3) Pr...

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Abstract

The invention discloses a chitosan / HA-based personalized cranial, maxillofacial and vertebral repair material and a preparation method thereof, which is prepared from a DCPD‑CS mixed solution, lecithin, cholesterol and pectin, and effectively improves the The mechanical properties of chitosan material, the bending strength is up to 173MPa, and the bending modulus is up to 8.6 GPa, which can meet the requirements of bone defect repair in the cranium, maxillofacial, spine, limb bones and other load-bearing parts. The material has good biocompatibility, can be degraded and absorbed, and can significantly induce the repair and regeneration of bone defects. It avoids the shortcomings of non-absorbable materials such as titanium alloy and PEEK that are stored in the body for a long time, and also avoids the inflammatory reaction of PLA and other absorbable materials. Poor bone formation and other issues. The present invention carries out personalized design and manufacture according to the CT scan of the patient's bone defect, and the microporous structure, pore diameter, porosity, etc. of the material can be precisely controlled, and the degradation speed can be matched with the regeneration speed of different bone defects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a chitosan / HA-based personalized cranial, maxillofacial and vertebral repair material and a preparation method thereof. Background technique [0002] Clinically, there are more and more bone defects caused by tumor, infection, trauma and congenital malformation, which not only affect the external appearance and function of the patient, but also bring inconvenience to the life of the patient, and even threaten their life. For the treatment of bone defects in load-bearing parts such as the cranium, maxillofacial area, spine, and limb bones, the material needs to bear the force of the body in all directions after implantation, so there are high requirements for the mechanical properties of the material. [0003] At present, there are two types of bone defect repair materials commonly used in clinical practice: non-absorbable materials and absorbable materials. Non-absorbable m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/48A61L27/56A61L27/58
CPCA61L27/46A61L27/48A61L27/56A61L27/58A61L2430/02C08L5/08
Inventor 张其清张瑗邢永振袁平王临钊陈灵艳段治伟林越威
Owner 福建吉特瑞生物科技有限公司
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