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A rapid particle size distribution information measurement method based on magnetic nanoparticles

A magnetic nanoparticle and particle size distribution technology, which is applied in the direction of measuring devices, particle size analysis, particle and sedimentation analysis, etc., can solve the problems of low real-time measurement results of magnetic nanoparticle size distribution information, long time-consuming measurement process, etc. Achieve the effect of solving real-time rapid particle size distribution information measurement and improving time resolution

Active Publication Date: 2022-02-08
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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Problems solved by technology

[0004] Aiming at the technical problems that the existing method for measuring particle size distribution may have false oscillations, the measurement process takes a long time, and the measurement results of magnetic nanometer particle size distribution information are not real-time, the present invention proposes a fast particle size distribution method based on magnetic nanoparticles The information measurement method can realize fast and real-time particle size distribution information measurement for magnetic nanometers, so as to meet the fast real-time particle size distribution information measurement required in medical biological diagnosis

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  • A rapid particle size distribution information measurement method based on magnetic nanoparticles
  • A rapid particle size distribution information measurement method based on magnetic nanoparticles
  • A rapid particle size distribution information measurement method based on magnetic nanoparticles

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[0141] 1. Simulation conditions

[0142] Carry out three groups of simulation experiments in order to study the effectiveness and superiority of the present invention, the first group of simulation parameters: Boltzmann's constant k B =1.38×10 -23 JK -1 , vacuum permeability μ 0 =1, saturation magnetization M s =47.7*10 4 , the absolute temperature T=290K, the excitation magnetic field frequency is 200Hz, the sampling rate is 100KHz, the range of the AC magnetic field strength is 0.00005Tesla---0.005Tesla, and the step is 0.0001Tesla. The particle size range is 0.5nm-50nm, and the particle size distribution parameters are μ=log(25.8), σ=0.2. The second set of simulation parameters: Boltzmann constant k B =1.38×10 -23 JK -1 , vacuum permeability μ 0 =1, saturation magnetization M s =47.7*10 4 , the absolute temperature T=290K, the frequency of the excitation magnetic field is 200Hz, the sampling rate is 100KHz, the range of the intensity of the AC magnetic field is 0...

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Abstract

The invention proposes a method for measuring fast particle size distribution information based on magnetic nanoparticles, the steps of which are as follows: the magnetic nano sample is placed at the object to be measured; a single-frequency sine wave excitation magnetic field is applied to the magnetic nano sample; Measure the magnetization response signal; use band-pass filter, low-noise preamplifier and frequency-selective amplifier to perform signal conditioning on the magnetization response signal; use harmonic amplitude detection algorithm to extract harmonic amplitude information; construct harmonic The functional relationship between the wave amplitude information and the particle size distribution information; set different excitation magnetic field strengths, and obtain Z different harmonic amplitude information and the functional relationship between the particle size distribution information to form a mathematical model; solve the particle size distribution information. The invention can obtain the magnetic nano particle size distribution information in real time and quickly, fundamentally solves the problem of low real-time measurement of the magnetic nano particle size distribution, and at the same time avoids the difficult problem of high-order harmonic measurement.

Description

technical field [0001] The invention relates to the technical field of nano-magnetic detection technology and non-invasive particle size distribution measurement, in particular to a method for rapidly measuring particle size distribution information based on magnetic nanoparticles, which is suitable for the analysis and analysis of magnetic nanometer characteristic information in medical biological diagnosis technology. Fast and precise measurements. Background technique [0002] Magnetic nanoparticles have been widely studied in biomedical applications, not only for hyperthermia of tumor cells, targeted drug delivery, detection of living biological events, but also for biomarkers, such as magnetic nanoparticle probes instead of fluorescent protein nanoparticles . The unique and excellent magnetic properties of magnetic nanoparticles have also opened up new detection technologies and measurement methods, such as magnetic nanoparticle imaging (MPI), magnetic nanoparticle the...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/02
CPCG01N15/02
Inventor 杜中州叶娜孙毅王丹丹苏日建刘文中甘勇李娜娜邹东尧金保华朱付保
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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