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Use of memantine hydrochloride (MEM) to prevention and/or treatment of diseases caused by bacterial infection

A technology of memantine hydrochloride and bacterial infection, which is applied in the fields of resisting vector-borne diseases, antibacterial drugs, and medical preparations containing active ingredients, to achieve the effect of low toxicity, high targeting, and strong targeting.

Inactive Publication Date: 2019-08-30
黄胜和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main challenge for the current treatment of bacterial meningitis is: how to take effective measures to intervene in this triad, and whether there is a drug that can simultaneously inhibit this triad

Method used

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  • Use of memantine hydrochloride (MEM) to prevention and/or treatment of diseases caused by bacterial infection
  • Use of memantine hydrochloride (MEM) to prevention and/or treatment of diseases caused by bacterial infection
  • Use of memantine hydrochloride (MEM) to prevention and/or treatment of diseases caused by bacterial infection

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Embodiment Construction

[0040] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0041] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used herein, the term "and / or" includes any and all combinations of one or more of ...

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Abstract

The invention discloses use of memantine hydrochloride (MEM) to prevention and / or treatment of diseases caused by bacterial infection. The memantine hydrochloride achieves the sterilization effect through neutrophil and a neutrophil extracellular trap so as to prevent and treat the diseases caused by the bacterial infection. The invention further discloses the use of united usage of the memantinehydrochloride and an antibiotic to preparation of a medicine for preventing and / or treating the diseases caused by the bacterial infection. Cells, a mouse model and the neutrophil extracellular trap are used, techniques of cell invasion, cell migration, mouse bacterial invasion, next-generation sequencing and the like are used, the anti-bacterium action mechanism of the MEM is researched, and through restraining alpha 7nAChR mediation, bacteremia / septicaemia and the diseases caused by the bacterial infection including bacterial meningitis can be effectively blocked.

Description

technical field [0001] The present invention relates to the technical field of pharmaceutical use, in particular to the use of memantine hydrochloride (MEM) in preventing and / or treating diseases caused by bacterial infections. Background technique [0002] Multi-drug resistant bacteria does not refer to a certain kind of bacteria in particular, but generally refers to those bacteria that are resistant to multiple antibiotics, commonly known as superbugs. Such bacteria can have strong resistance to antibiotics and can escape the danger of being killed. At present, the super bacteria that have attracted special attention mainly include: methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus pneumoniae (MDRSP), vancomycin enterococcus (VRE), multidrug-resistant Mycobacterium tuberculosis (MDR- TB), multidrug-resistant Acinetobacter baumannii (MRAB), and the newly discovered Escherichia coli and Klebsiella pneumoniae carrying the NDM-1 gene, etc....

Claims

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Application Information

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IPC IPC(8): A61K31/13A61K31/43A61P31/04
CPCA61K31/13A61K31/43A61P31/04A61K2300/00Y02A50/30
Inventor 黄胜和
Owner 黄胜和
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