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Use of modified thymosin β4 in the treatment of radiation enteritis

A radiation enteritis, thymosin technology, applied in the field of disease treatment, can solve the problems of poor recovery and large patient damage.

Active Publication Date: 2022-02-22
BEIJING NORTHLAND BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Once it occurs, the clinical treatment mainly depends on surgery, which not only causes great damage to the patient, but also has many complications, and the prognosis is relatively poor.

Method used

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  • Use of modified thymosin β4 in the treatment of radiation enteritis
  • Use of modified thymosin β4 in the treatment of radiation enteritis
  • Use of modified thymosin β4 in the treatment of radiation enteritis

Examples

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Effect test

Embodiment

[0041] In this example, the effect of the modified recombinant human thymosin β4 on the treatment of radiation enteritis was evaluated through a mouse model of radiation enteritis.

[0042] 1. Materials and methods

[0043] 1.1 Drugs:

[0044] Modified recombinant human thymosin β4 (hereinafter referred to as rhG-Tβ4 and rhA-Tβ4), provided by Beijing Northland Biotechnology Co., Ltd., the batch number is C-20180101 (its sequence is shown in SEQ ID NO: 1) and C-20180315 (its sequence is shown in SEQ ID NO: 2); specification: 100 μg / cartridge. Prepare the required concentration with physiological saline immediately before use.

[0045] The natural structure of human thymosin β4 is chemically synthesized by Shanghai Taishi Biotechnology Co., Ltd. (hereinafter referred to as cTβ4), and it is prepared to the required concentration with normal saline before use.

[0046] 1.2 Instruments:

[0047] EG1160 paraffin embedding machine, a product of Leica, Germany;

[0048] RM2255 ...

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Abstract

The title of the invention is "Use of Modified Thymosin β4 in Treating Radiation Enteritis", and relates to the technical field of radiation enteritis disease treatment. The technical problem to be solved is: radiation enteritis is currently mainly treated by surgery, which causes relatively large damage to the patient, complications, and poor prognosis. Although studies have shown that the natural structure thymosin β4 has a certain effect on colitis. Therapeutic effect, but the dosage is higher. Compared with the natural thymosin β4, the modified thymosin β4 structure selected by the present invention can significantly reduce the dosage, which is of great significance for the treatment of radiation enteritis. The key points of the technical solution are: mainly adopt the modified thymosin β4 structure and the natural thymosin β4 to study the animal model of radiation enteritis, and compare the dosage and therapeutic effect; in terms of main application, the modified thymosin β4 of the present invention is used for Use in the treatment of radiation enteritis in subjects.

Description

technical field [0001] The present invention relates to the field of disease treatment. In particular, the present invention relates to the use of modified thymosin β4 for treating radiation enteritis in a subject (for example, human), and in the preparation of a drug for treating radiation enteritis in a subject (for example, human). Drug use. The present invention also relates to a method for treating radiation enteritis, which includes the step of administering the modified thymosin β4 to a subject in need thereof. Background technique [0002] Statistics from Shadad AK et al. (Gastrointestinal radiation injury: prevention and treatment. World J Gastroenterol, 2013, 19:199-208) show that radiation therapy plays a key role in the treatment of tumors, and about 70% of tumor patients have received radiation With the popularization of radiation therapy in malignant tumors, the incidence of radiation enteritis (RE) is increasing year by year (Clinical risk factors for late i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/22A61K9/08A61K9/19A61P1/00A61P1/12
CPCA61K38/2292A61K9/0019A61K9/08A61K9/19A61P1/00A61P1/12
Inventor 聂李亚许松山马素永马杉姗汤晓闯
Owner BEIJING NORTHLAND BIOTECH
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