36 results about "Chronic radiation enteropathy" patented technology

The present invention provides conformationally-defined macrocyclic compounds that bind to and / or are functional modulators of the motilin receptor including subtypes, isoforms and / or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and / or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, C. difficile associated diarrhea, traveller's diarrhea, diarrhea induced by graph versus host disease, other types of diarrhea, dyspepsia, irritable bowel syndrome, chemotherapy-induced nausea and vomiting (emesis) and post-operative nausea and vomiting and functional gastrointestinal disorders. In addition, the compounds possess utility for the treatment of diseases and disorders characterized by poor stomach or intestinal absorption, such as short bowel syndrome, celiac disease and cachexia. The compounds also have use for the treatment of inflammatory diseases and disorders of the gastrointestinal tract, such as inflammatory bowel disease, ulcerative colitis, Crohn's disease and pancreatitis. Accordingly, methods of treating such disorders and pharmaceutical compositions including compounds of the present invention are also provided.

The invention belongs to pharmaceutical preparations containing protein materials. It is an oral preparation of intestinal trefoil factor, which is characterized in that it contains intestinal trefoil factor as a pharmacodynamic active component, and also contains intestinal trefoil factor activator and intestinal trefoil factor protective agent. It is clinically used for the treatment of gastrointestinal ischemia-hypoxic injury, such as peptic ulcer, radiation enteritis, chronic gastritis, enteritis and other diseases caused by various reasons, and can rapidly promote the proliferation of gastrointestinal epithelial cells, Stabilizes the gastrointestinal mucus layer, does not interfere with glucose metabolism and promote gluconeogenesis, and has no side effects of promoting the expression of bacterial drug resistance genes and promoting the growth of tumor cells.

The invention discloses an enema for treating radiation proctitis. Radiation enteritis belongs to the category of "diarrhea" and "dysentery" in traditional Chinese medicine. For this reason, the present invention selects to have with heat-clearing and toxic substances removing, detumescence and hemostasis, the Chinese medicine narcissus, purple ginseng, cassia root, cassia seed, toon alba, nasturtium, purple pearl leaf, big thistle, lotus leaf, Sophora japonica, Mulberry fruit, Atractylodes macrocephala, longan core, and honey are used to make enemas. Through clinical trials in our hospital, the total effective rate of the treatment group is 91.3%, which is better than that of the control group, which is 78.3%. No side effects, worthy of clinical application.

The invention relates to a Chinese medicinal preparation used for treating radiation enteritis. The Chinese medicinal preparation used for treating the radiation enteritis comprises the following effective raw material components: all-grass of broadleaf ainslaea, humifuse euphorbia herb, melastoma dodecandrum, calamint, lotus petiole, gynostemma pentaphyllum, chinese amphibious knotweed rhizome, meadowrue root and rhizome, gray polypody, sea-buckthorn, clematis finetiana, cactus, polygonum hydropiper, sago seed, fortune paulownia flower and screwtree root. The Chinese medicinal preparation used for treating the radiation enteritis has the effects of tonifying qi, nourishing yin, removing heat to promote salivation, astringe intestine to stop bleeding and astringing to stop pain and has a good treatment effect on radiation enteritis caused by a radioactive factor; the selected medicinal raw materials are available; the Chinese medicinal preparation used for treating the radiation enteritis is easy to make, low in cost and obvious in curative effect, can treat both symptoms and root causes and has no toxic and side effect; dialectical treatment is carried out according to a clinical disease, and the total effective rate of treatment on the radiation enteritis can be up to 98%.

An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and / or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.

The invention discloses a composition treating colorectal cancer and applications of medicines treating colorectal cancer. The composition comprises the following ingredients containing treatment effective doses: any one or two of ground beetle and gekko swinhonis seu japonicus, any one or two of peach seeds and curcuma rhizome, any one or two of radix sophorae flavescentis and patrinia herb, any one or two of smilax glabra and cortex moutan, any one or two of garden burnet and barbat skullcap, any one or two of sophora flowers and pseudobulubs cremastrae seu pleiones, and any one or two of dandelion and manyleaf paris rhizome. The composition is provided in an ingredient ratio less than a poisonous dose. The composition also can comprise coix seeds or radix scrophulariae, and is used combined with chemotherapeutants further. The composition is suitable for colorectal cancer patients with current known various symptoms, can inhibit precancerous lesions effectively, improves mucous bloody stool of intestinal cancer patients, relieves radiation enteritis, raises life quality of intestinal cancer patients and provides a forward life expectancy with definite and objective therapeutic effects for intestinal cancer patients.

The invention discloses a traditional Chinese medicine enema used for treating radiation enteritis. In traditional Chinese medical science, the radiation enteritis belongs to the categories of 'diarrhoea' and 'stomachache', and pathogenesis comprises deficient root with overdo superficial, pathogenic heat entering the interior and temperament depletion. Thus, traditional Chinese medicines with the effects of clearing away heat and toxic materials, tonifying deficiency and dehumidifying, stopping bleeding and eliminating inflammation and relieving diarrhea with astringents, such as clerodendrum fortunatum root, houttuynia cordata, japanese claw fern herb, souliea vaginata, golden cypress, white atractylodes rhizome, tortuous knotweed root, limonite, Japanese beauty-berry leaf, ferrugineous ask bark, crinis trachycarpi and liquorice are selected and prepared into the enema by a medicine preparation room of a hospital (described in the specification), clinical test shows that the total effective rate is 95.1% and is obviously better than that of a control group, and recovery time is shorter than that of the control group, so that the traditional Chinese medicine enema is worthy of clinical popularization and application.