Preparation method and clinical application of larix gmelini arabinogalactan composition

A technology of arabinogalactan and larch, which is applied in the field of biotechnology and medicine, to achieve the effect of complete extraction and energy saving

Pending Publication Date: 2019-09-20
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, the drug intake of medical methods will have many side

Method used

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  • Preparation method and clinical application of larix gmelini arabinogalactan composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Method for preparing larch arabinogalactan composition

[0050] S1. Extract arabinogalactan from larch; the specific steps are as follows:

[0051] Wash the roots of cultivated larch trees that are more than 35 years old, cut them into small pieces of wood chips with a cutting machine, and then crush them into small particles. The water content of the wood chips is 35%. Take 10kg of the above wood chips and use 10 times 95%. Soak in ethanol treatment and continuously stir for 4 hours, stand still for 10 hours, centrifuge and filter to obtain the filter residue, remove the ethanol in the filter residue, add 4 times the amount of water to the filter residue and place it in an ultra-high pressure device, treat it with 300 MPa for 15 minutes, and filter it by centrifugation. The filtrate and the filter residue, the filter residue was again added with 6 times the amount of water, stirred for 2 hours, stayed overnight, filtered to obtain the filtrate, the two filtrates were combin...

Embodiment 2

[0057] Method for preparing larch arabinogalactan composition

[0058] S1. Extract arabinogalactan from larch; the specific steps are as follows:

[0059] Wash the roots of cultivated larch trees that are more than 35 years old, cut them into small wood chips with a cutting machine, and then crush them into small particles. The water content of the wood chips is 35%. Take the above wood chips and first use 10 times 95% ethanol. Soak and stir continuously for 4 hours, stand still for 10 hours, centrifuge and filter to obtain the filter residue, remove the ethanol in the filter residue, add 4 times the amount of water to the filter residue and place it in the ultra-high pressure device, treat it with 350 MPa for 15 minutes, and filter the filtrate by centrifugation Add 6 times the amount of water to the filter residue again, stir for 2 hours, stand still overnight, filter to obtain the filtrate, combine the two filtrates, concentrate to a certain volume, slowly add ethanol to make th...

Embodiment 3

[0065] Method for preparing larch arabinogalactan composition

[0066] S1. Extract arabinogalactan from larch; the specific steps are as follows:

[0067] Wash the roots of cultivated larch trees that are more than 35 years old, cut them into small wood chips with a cutting machine, and then crush them into small particles. The water content of the wood chips is 35%. Take the above wood chips and first use 10 times 95% ethanol. After treatment, soak and stir continuously for 4 hours, stand still for 10 hours, centrifuge and filter to obtain the filter residue, remove the ethanol in the filter residue, add 4 times the amount of water to the filter residue and place it in an ultra-high pressure device, treat with 400 MPa for 15 minutes, and filter to obtain the filtrate Add 6 times the amount of water to the filter residue again, stir for 2 hours, stand still overnight, filter to obtain the filtrate, combine the two filtrates, concentrate to a certain volume, slowly add ethanol to ma...

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Abstract

The invention belongs to the medical field of biotechnology medicine and discloses a preparation method and clinical application of larix gmelini arabinogalactan composition. The larix gmelini arabinogalactan composition comprises, by weight, 3-6 parts of larix gmelini arabinogalactan, 0.5-3 parts of inulin and 0.4-3 parts of coconut nut powder. The preparation method includes the steps of S1, extracting the arabinogalactan from larix gmelini; S2, preparing defatted coconut powder; sterilizing the finished product. The preparation method the advantage of low cost, static ultra-high pressure room temperature treatment is simple and easy to implement, a great deal of energy can be saved, and objects are extracted completely and thoroughly; the larix gmelini arabinogalactan composition is provided to be effective in the treatment of diarrhea irritable bowel syndrome by volunteer clinical trials, and drug therapy with certain side effects is replaced by dietary therapy.

Description

Technical field [0001] The present invention belongs to the field of biotechnology and medicine. The present invention relates to the compatibility of larch arabinogalactan and skimmed coconut powder composition, extraction preparation method, and instantaneous increase and reduced pressure sterilization technology; in particular, it relates to a larch arabinogalactan Preparation method of glycan composition and its clinical application. Background technique [0002] Arabinogalactan (AG) exists in a variety of plants. Larch is currently the plant with the most abundant arabinogalactan content found in the world. Larix arabinogalactan is mainly distributed in the early wood of the heartwood of larch In the tracheid cell cavity of late wood, a small amount is present in ray cells and adipocytes. Unlike other hemicelluloses, at least 90% of arabinogalactan is located outside the cell wall of larch ( Etc., 1966; And Westermark, 1999), mainly filled in tracheids, therefore, the extr...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/14A61K47/46A61P1/00A61L2/02
CPCA61K31/733A61K31/715A61K9/148A61P1/00A61L2/0011A61L2202/121A61L2202/21
Inventor 郑双阳张伟丁传波高飞飞
Owner DALIAN UNIVERSITY
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