A natural isochromanone compound for lowering blood pressure

An isochromanone and compound technology, applied in the field of natural compounds, can solve the problems of less research on other components, and achieve the effects of excellent antihypertensive effect, reduced solvent consumption, and shortened extraction time.

Active Publication Date: 2021-02-05
河北省农林科学院经济作物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on Uncaria extract focuses on Rhynchophylline, and there are few studies on other ingredients

Method used

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  • A natural isochromanone compound for lowering blood pressure
  • A natural isochromanone compound for lowering blood pressure
  • A natural isochromanone compound for lowering blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: the extraction separation of the isochroman ketone compound of formula (I)

[0053] The method is as follows:

[0054] (i) Get 1.0Kg of hooked stems and branches of dried Uncaria tomentosa (Uncaria tomentosa), thoroughly pulverize and cross a 100-mesh sieve to get Uncaria tomentosa powder;

[0055] (ii) Put the Uncaria powder into a single-stage continuous countercurrent ultrasonic extractor after mixing it with 8L of 80% ethanol aqueous solution, set the frequency of the ultrasonic wave to 60KHz, the power is 300W, and extract at 40°C for 90min; After the extraction, repeat the extraction twice, and combine all the extracts;

[0056] (iii) The combined extract is distilled under reduced pressure to reclaim the solvent, and the degree of concentration is suitable for the volume of the concentrated solution and the amount of Uncaria uncariae, to obtain the concentrated solution I, which is about 1L;

[0057] (iv) Add 1 times the volume of water to the con...

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Abstract

The invention relates to a natural isochromanone compound. The compound has an excellent antihypertensive effect on both the blood pressure of spontaneously hypertensive rats (SHR) and the blood pressure of C57BL / 6 mice mediated by angiotensin II, and a unique effect of the compound on prevention and treatment of the hypertension is shown. The compound is derived from uncaria tomentosa, has rich sources, can be obtained through simple and convenient extraction and separation processes, and can be prepared on a large scale.

Description

technical field [0001] The present invention relates to the technical field of natural compounds. Specifically, the present invention relates to a novel natural isochromanone compound for lowering blood pressure, which is derived from the traditional Chinese medicine Uncaria. The present invention also relates to the extraction and separation method and application of the compound. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. It leads to increased morbidity and mortality of congestive heart failure, stroke, coronary heart disease, renal failure, and aortic aneurysm. major risk factors. There are about 1 billion people with hypertension in the world, and my country accounts for about 1 / 5 of them. The prevalence rate of hypertension is 18.8%, which is equivalent to 2 people in every 10 people suffer from hypertension. However, the compliance rate of hypertension in my country is only 6.1%, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/76A61P9/12A61K31/352
CPCA61P9/12C07D311/76
Inventor 贾东升谢晓亮魏曼温春秀崔施展王腾刘灵娣田伟
Owner 河北省农林科学院经济作物研究所
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